Ferroptosis; Gene Correction; Induced Pluripotent Stem Cells; Iron Chelation; Leukodystrophy; Myelination; Oligodendrocyte; Patient Models

Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation

Pelizaeus-Merzbacher disease (PMD) is an X-linked leukodystrophy caused by mutations in Proteolipid Protein 1 (PLP1), encoding a major …

Hiroko Nobuta, Nan Yang, Yi Han Ng, Samuele G Marro, Khalida Sabeur, Manideep Chavali, John H Stockley, David W Killilea, Patrick B Walter, Chao Zhao, Jr, Philip Huie, Steven a Goldman, Arnold R Kriegstein, MD, PhD, Robin J M Franklin, David H Rowitch, Marius Wernig