Orienting fate: spatial regulation of neurogenic divisions

Abstract

Cleavage plane orientation has been thought to govern the fate of neural stem cell progeny, but supporting evidence in the neocortex has been sparse. A new study by Postiglione et al. in this issue of Neuron shows that mouse Inscuteable-mediated control of cleavage plane orientation regulates the output of neural progenitor cells.

Type
Publication
Neuron
Arnold R Kriegstein, MD, PhD
Arnold R Kriegstein, MD, PhD
Professor of Neurology