Kriegstein Lab
Kriegstein Lab
Datasets
People
Publications
Contact
Publications
Type
Journal article
Date
2022
2021
2020
2019
2018
2017
2016
2015
2014
2013
2012
2011
2010
2009
2008
2007
2006
2005
2004
2003
2002
2001
2000
1999
1998
1997
1996
1995
1992
1991
1990
1989
1988
1987
1986
1985
1983
1982
1977
1974
How mechanisms of stem cell polarity shape the human cerebral cortex
Apical-basal progenitor cell polarity establishes key features of the radial and laminar architecture of the developing human cortex. …
Madeline G Andrews
,
Lakshmi Subramanian
,
Jahan Salma
,
Arnold R Kriegstein
Cite
Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain
Interactions between angiogenesis and neurogenesis regulate embryonic brain development. However, a comprehensive understanding of the …
Elizabeth E Crouch
,
Aparna Bhaduri
,
Madeline G Andrews
,
Arantxa Cebrian-Silla
,
Loukas N Diafos
,
Janeth Ochoa Birrueta
,
Kaylee Wedderburn-Pugh
,
Edward J Valenzuela
,
Neal K Bennett
,
Ugomma C Eze
,
Carmen Sandoval Espinosa
,
Jiapei Chen
,
Cristina Mora
,
Jayden M Ross
,
Clare E Howard
,
Susana Gonzalez-Granero
,
Jaime Ferrer Lozano
,
Maximo Vento
,
Maximilian Haeussler
,
Mercedes F Paredes
,
Ken Nakamura
,
Jose Manuel Garcia-Verdugo
,
Arturo Alvarez-Buylla
,
Arnold R Kriegstein
,
Eric J Huang
Cite
A nomenclature consensus for nervous system organoids and assembloids
Self-organizing three-dimensional cellular models derived from human pluripotent stem cells or primary tissue have great potential to …
Sergiu P Pașca
,
Paola Arlotta
,
Helen S Bateup
,
J Gray Camp
,
Silvia Cappello
,
Fred H Gage
,
Jürgen A Knoblich
,
Arnold R Kriegstein
,
Madeline A Lancaster
,
Guo-Li Ming
,
Alysson R Muotri
,
In-Hyun Park
,
Orly Reiner
,
Hongjun Song
,
Lorenz Studer
,
Sally Temple
,
Giuseppe Testa
,
Barbara Treutlein
,
Flora M Vaccarino
Cite
Zika virus alters centrosome organization to suppress the innate immune response
Zika virus (ZIKV) is a flavivirus transmitted via mosquitoes and sex to cause congenital neurodevelopmental defects, including …
Andrew Kodani
,
Kristeene A Knopp
,
Elizabeth Di Lullo
,
Hanna Retallack
,
Arnold R Kriegstein
,
Joseph L DeRisi
,
Jeremy F Reiter
Cite
Tropism of SARS-CoV-2 for human cortical astrocytes
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) readily infects a variety of cell types impacting the function of …
Madeline G Andrews
,
Tanzila Mukhtar
,
Ugomma C Eze
,
Camille R Simoneau
,
Jayden Ross
,
Neelroop Parikshak
,
Shaohui Wang
,
Li Zhou
,
Mark Koontz
,
Dmitry Velmeshev
,
Clara-Vita Siebert
,
Kaila M Gemenes
,
Takako Tabata
,
Yonatan Perez
,
Li Wang
,
Mohammed A Mostajo-Radji
,
Martina de Majo
,
Kevin C Donohue
,
David Shin
,
Jahan Salma
,
Alex A Pollen
,
Tomasz J Nowakowski
,
Erik Ullian
,
G Renuka Kumar
,
Ethan A Winkler
,
Elizabeth E Crouch
,
Melanie Ott
,
Arnold R Kriegstein
Cite
Identification of Lipid Heterogeneity and Diversity in the Developing Human Brain
The lipidome is currently understudied but fundamental to life. Within the brain, little is known about cell-type lipid heterogeneity, …
Aparna Bhaduri
,
Elizabeth K Neumann
,
Arnold R Kriegstein
,
Jonathan V Sweedler
Cite
An atlas of cortical arealization identifies dynamic molecular signatures
The human brain is subdivided into distinct anatomical structures, including the neocortex, which in turn encompasses dozens of …
Aparna Bhaduri
,
Carmen Sandoval Espinosa
,
Marcos Otero-Garcia
,
Irene Oh
,
Raymund Yin
,
Ugomma C Eze
,
Tomasz J Nowakowski
,
Arnold R Kriegstein
Cite
Distinct nuclear compartment-associated genome architecture in the developing mammalian brain
Nuclear compartments are thought to play a role in three-dimensional genome organization and gene expression. In mammalian brain, the …
Sajad Hamid Ahanger
,
Ryan N Delgado
,
Eugene Gil
,
Mitchel A Cole
,
Jingjing Zhao
,
Sung Jun Hong
,
Arnold R Kriegstein
,
Tomasz J Nowakowski
,
Alex A Pollen
,
Daniel A Lim
Cite
Human intermediate progenitor diversity during cortical development
Studies of the spatiotemporal, transcriptomic, and morphological diversity of radial glia (RG) have spurred our current models of human …
Mark-Phillip Pebworth
,
Jayden Ross
,
Madeline Andrews
,
Aparna Bhaduri
,
Arnold R Kriegstein
Cite
Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia
The human cortex comprises diverse cell types that emerge from an initially uniform neuroepithelium that gives rise to radial glia, the …
Ugomma C Eze
,
Aparna Bhaduri
,
Maximilian Haeussler
,
Tomasz J Nowakowski
,
Arnold R Kriegstein
Cite
Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) readily infects a variety of cell types impacting the function of …
Madeline G Andrews
,
Tanzila Mukhtar
,
Ugomma C Eze
,
Camille R Simoneau
,
Yonatan Perez
,
Mohammed A Mostajo-Radji
,
Shaohui Wang
,
Dmitry Velmeshev
,
Jahan Salma
,
G Renuka Kumar
,
Alex A Pollen
,
Elizabeth E Crouch
,
Melanie Ott
,
Arnold R Kriegstein
Cite
Cell-type-specific 3D epigenomes in the developing human cortex
Lineage-specific epigenomic changes during human corticogenesis have been difficult to study owing to challenges with sample …
Michael Song
,
Mark-Phillip Pebworth
,
Xiaoyu Yang
,
Armen Abnousi
,
Changxu Fan
,
Jia Wen
,
Jonathan D Rosen
,
Mayank N K Choudhary
,
Xiekui Cui
,
Ian R Jones
,
Seth Bergenholtz
,
Ugomma C Eze
,
Ivan Juric
,
Bingkun Li
,
Lenka Maliskova
,
Jerry Lee
,
Weifang Liu
,
Alex A Pollen
,
Yun Li
,
Ting Wang
,
Ming Hu
,
Arnold R Kriegstein
,
Yin Shen
Cite
Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies
CD19-directed immunotherapies are clinically effective for treating B cell malignancies but also cause a high incidence of …
Kevin R Parker
,
Denis Migliorini
,
Eric Perkey
,
Kathryn E Yost
,
Aparna Bhaduri
,
Puneet Bagga
,
Mohammad Haris
,
Neil E Wilson
,
Fang Liu
,
Khatuna Gabunia
,
John Scholler
,
Thomas J Montine
,
Vijay G Bhoj
,
Ravinder Reddy
,
Suyash Mohan
,
Ivan Maillard
,
Arnold R Kriegstein
,
Carl H June
,
Howard Y Chang
,
Jr, Avery D Posey
,
Ansuman T Satpathy
Cite
mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex
Outer radial glial (oRG) cells are a population of neural stem cells prevalent in the developing human cortex that contribute to its …
Madeline G Andrews
,
Lakshmi Subramanian
,
Arnold R Kriegstein
Cite
Are Organoids Ready for Prime Time?
Innovations in organoid-based models of human tissues have made them an exciting experimental platform for studying development and …
Aparna Bhaduri
,
Madeline G Andrews
,
Arnold R Kriegstein
,
Tomasz J Nowakowski
Cite
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency
Aberrant aggregation of the RNA-binding protein TDP-43 in neurons is a hallmark of frontotemporal lobar degeneration caused by …
Jiasheng Zhang
,
Dmitry Velmeshev
,
Kei Hashimoto
,
Yu-Hsin Huang
,
Jeffrey W Hofmann
,
Xiaoyu Shi
,
Jiapei Chen
,
Andrew M Leidal
,
Julian G Dishart
,
Michelle K Cahill
,
Kevin W Kelley
,
Shane A Liddelow
,
William W Seeley
,
Bruce L Miller
,
Tobias C Walther
,
Jr, Robert V Farese
,
J Paul Taylor
,
Erik M Ullian
,
Bo Huang
,
Jayanta Debnath
,
Torsten Wittmann
,
Arnold R Kriegstein
,
Eric J Huang
Cite
Origins and Proliferative States of Human Oligodendrocyte Precursor Cells
Human cerebral cortex size and complexity has increased greatly during evolution. While increased progenitor diversity and enhanced …
Wei Huang
,
Aparna Bhaduri
,
Dmitry Velmeshev
,
Shaohui Wang
,
Li Wang
,
Catherine A Rottkamp
,
Arturo Alvarez-Buylla
,
David H Rowitch
,
Arnold R Kriegstein
Cite
A Chromatin Accessibility Atlas of the Developing Human Telencephalon
To discover regulatory elements driving the specificity of gene expression in different cell types and regions of the developing human …
Eirene Markenscoff-Papadimitriou
,
Sean Whalen
,
Pawel Przytycki
,
Reuben Thomas
,
Fadya Binyameen
,
Tomasz J Nowakowski
,
Arnold R Kriegstein
,
Stephan J Sanders
,
Matthew W State
,
Katherine S Pollard
,
John L Rubenstein
Cite
Identification of amygdala-expressed genes associated with autism spectrum disorder
BACKGROUND: Studies of individuals with autism spectrum disorder (ASD) have revealed a strong multigenic basis with the identification …
Maria Jesus Herrero
,
Dmitry Velmeshev
,
David Hernandez-Pineda
,
Saarthak Sethi
,
Shawn Sorrells
,
Payal Banerjee
,
Catherine Sullivan
,
Abha R Gupta
,
Arnold R Kriegstein
,
Joshua G Corbin
Cite
SMART-Q: An Integrative Pipeline Quantifying Cell Type-Specific RNA Transcription
Accurate RNA quantification at the single-cell level is critical for understanding the dynamics of gene expression and regulation …
Xiaoyu Yang
,
Seth Bergenholtz
,
Lenka Maliskova
,
Mark-Phillip Pebworth
,
Arnold R Kriegstein
,
Yun Li
,
Yin Shen
Cite
Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog
Neural stem cells (NSCs) in the prenatal neocortex progressively generate different subtypes of glutamatergic projection neurons. …
Yue Zhang
,
Guoping Liu
,
Teng Guo
,
Xiaoyi G Liang
,
Heng Du
,
Lin Yang
,
Aparna Bhaduri
,
Xiaosu Li
,
Zhejun Xu
,
Zhuangzhi Zhang
,
Zhenmeiyu Li
,
Miao He
,
Jeremiah Tsyporin
,
Arnold R Kriegstein
,
John L Rubenstein
,
Zhengang Yang
,
Bin Chen
Cite
Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma
Glioblastoma is a devastating form of brain cancer. To identify aspects of tumor heterogeneity that may illuminate drivers of tumor …
Aparna Bhaduri
,
Elizabeth Di Lullo
,
Diane Jung
,
Sören Müller
,
Elizabeth Erin Crouch
,
Carmen Sandoval Espinosa
,
Tomoko Ozawa
,
Beatriz Alvarado
,
Julien Spatazza
,
Cathryn René Cadwell
,
Grace Wilkins
,
Dmitry Velmeshev
,
Siyuan John Liu
,
Martina Malatesta
,
Madeline Gail Andrews
,
Mohammed Andres Mostajo-Radji
,
Eric Jinsheng Huang
,
Tomasz Jan Nowakowski
,
Daniel Amos Lim
,
Aaron Diaz
,
David Ronan Raleigh
,
Arnold Richard Kriegstein
Cite
Cell stress in cortical organoids impairs molecular subtype specification
Cortical organoids are self-organizing three-dimensional cultures that model features of the developing human cerebral cortex(1,2). …
Aparna Bhaduri
,
Madeline G Andrews
,
Walter Mancia Leon
,
Diane Jung
,
David Shin
,
Denise Allen
,
Dana Jung
,
Galina Schmunk
,
Maximilian Haeussler
,
Jahan Salma
,
Alex A Pollen
,
Tomasz J Nowakowski
,
Arnold R Kriegstein
Cite
Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation
Pelizaeus-Merzbacher disease (PMD) is an X-linked leukodystrophy caused by mutations in Proteolipid Protein 1 (PLP1), encoding a major …
Hiroko Nobuta
,
Nan Yang
,
Yi Han Ng
,
Samuele G Marro
,
Khalida Sabeur
,
Manideep Chavali
,
John H Stockley
,
David W Killilea
,
Patrick B Walter
,
Chao Zhao
,
Jr, Philip Huie
,
Steven A Goldman
,
Arnold R Kriegstein
,
Robin J M Franklin
,
David H Rowitch
,
Marius Wernig
Cite
Neuroglial stem cell-derived inflammatory pseudotumor (n-SCIPT): clinicopathologic characterization of a novel lesion of the lumbosacral spinal cord and nerve roots following intrathecal allogeneic stem cell intervention
Emily A Sloan
,
Paul J Sampognaro
,
Jacqueline C Junn
,
Cynthia Chin
,
Line Jacques
,
Prashanth S Ramachandran
,
Joseph L DeRisi
,
Michael R Wilson
,
Arnold R Kriegstein
,
Andrew W Bollen
,
David A Solomon
,
Marta Margeta
,
John W Engstrom
Cite
Neuronal vulnerability and multilineage diversity in multiple sclerosis
Multiple sclerosis (MS) is a neuroinflammatory disease with a relapsing-remitting disease course at early stages, distinct lesion …
Lucas Schirmer
,
Dmitry Velmeshev
,
Staffan Holmqvist
,
Max Kaufmann
,
Sebastian Werneburg
,
Diane Jung
,
Stephanie Vistnes
,
John H Stockley
,
Adam Young
,
Maike Steindel
,
Brian Tung
,
Nitasha Goyal
,
Aparna Bhaduri
,
Simone Mayer
,
Jan Broder Engler
,
Omer A Bayraktar
,
Robin J M Franklin
,
Maximilian Haeussler
,
Richard Reynolds
,
Dorothy P Schafer
,
Manuel A Friese
,
Lawrence R Shiow
,
Arnold R Kriegstein
,
David H Rowitch
Cite
Immature excitatory neurons develop during adolescence in the human amygdala
The human amygdala grows during childhood, and its abnormal development is linked to mood disorders. The primate amygdala contains a …
Shawn F Sorrells
,
Mercedes F Paredes
,
Dmitry Velmeshev
,
Vicente Herranz-Pérez
,
Kadellyn Sandoval
,
Simone Mayer
,
Edward F Chang
,
Ricardo Insausti
,
Arnold R Kriegstein
,
John L Rubenstein
,
Jose Manuel Garcia-Verdugo
,
Eric J Huang
,
Arturo Alvarez-Buylla
Cite
Single-cell genomics identifies cell type-specific molecular changes in autism
Despite the clinical and genetic heterogeneity of autism, bulk gene expression studies show that changes in the neocortex of autism …
Dmitry Velmeshev
,
Lucas Schirmer
,
Diane Jung
,
Maximilian Haeussler
,
Yonatan Perez
,
Simone Mayer
,
Aparna Bhaduri
,
Nitasha Goyal
,
David H Rowitch
,
Arnold R Kriegstein
Cite
Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex
In the developing human neocortex, progenitor cells generate diverse cell types prenatally. Progenitor cells and newborn neurons …
Simone Mayer
,
Jiadong Chen
,
Dmitry Velmeshev
,
Andreas Mayer
,
Ugomma C Eze
,
Aparna Bhaduri
,
Carlos E Cunha
,
Diane Jung
,
Arpana Arjun
,
Emmy Li
,
Beatriz Alvarado
,
Shaohui Wang
,
Nils Lovegren
,
Michael L Gonzales
,
Lukasz Szpankowski
,
Anne Leyrat
,
Jay A A West
,
Georgia Panagiotakos
,
Arturo Alvarez-Buylla
,
Mercedes F Paredes
,
Tomasz J Nowakowski
,
Alex A Pollen
,
Arnold R Kriegstein
Cite
Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution
Direct comparisons of human and non-human primate brains can reveal molecular pathways underlying remarkable specializations of the …
Alex A Pollen
,
Aparna Bhaduri
,
Madeline G Andrews
,
Tomasz J Nowakowski
,
Olivia S Meyerson
,
Mohammed A Mostajo-Radji
,
Elizabeth Di Lullo
,
Beatriz Alvarado
,
Melanie Bedolli
,
Max L Dougherty
,
Ian T Fiddes
,
Zev N Kronenberg
,
Joe Shuga
,
Anne A Leyrat
,
Jay A West
,
Marina Bershteyn
,
Craig B Lowe
,
Bryan J Pavlovic
,
Sofie R Salama
,
David Haussler
,
Evan E Eichler
,
Arnold R Kriegstein
Cite
Neuroserpin expression during human brain development and in adult brain revealed by immunohistochemistry and single cell RNA sequencing
Neuroserpin is a serine-protease inhibitor mainly expressed in the CNS and involved in the inhibition of the proteolytic cascade. …
Istvan Adorjan
,
Teadora Tyler
,
Aparna Bhaduri
,
Samuel Demharter
,
Cintia Klaudia Finszter
,
Maria Bako
,
Oliver Marcell Sebok
,
Tomasz J Nowakowski
,
Konstantin Khodosevich
,
Kjeld Møllgård
,
Arnold R Kriegstein
,
Lei Shi
,
Anna Hoerder-Suabedissen
,
Olaf Ansorge
,
Zoltán Molnár
Cite
Does Adult Neurogenesis Persist in the Human Hippocampus?
Mercedes F Paredes
,
Shawn F Sorrells
,
Arantxa Cebrian-Silla
,
Kadellyn Sandoval
,
Dashi Qi
,
Kevin W Kelley
,
David James
,
Simone Mayer
,
Julia Chang
,
Kurtis I Auguste
,
Edward F Chang
,
Antonio J Gutierrez Martin
,
Arnold R Kriegstein
,
Gary W Mathern
,
Michael C Oldham
,
Eric J Huang
,
Jose Manuel Garcia-Verdugo
,
Zhengang Yang
,
Arturo Alvarez-Buylla
Cite
Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development
MicroRNAs (miRNAs) regulate many cellular events during brain development by interacting with hundreds of mRNA transcripts. However, …
Tomasz J Nowakowski
,
Neha Rani
,
Mahdi Golkaram
,
Hongjun R Zhou
,
Beatriz Alvarado
,
Kylie Huch
,
Jay A West
,
Anne Leyrat
,
Alex A Pollen
,
Arnold R Kriegstein
,
Linda R Petzold
,
Kenneth S Kosik
Cite
Identification of cell types in a mouse brain single-cell atlas using low sampling coverage
BACKGROUND: High throughput methods for profiling the transcriptomes of single cells have recently emerged as transformative approaches …
Aparna Bhaduri
,
Tomasz J Nowakowski
,
Alex A Pollen
,
Arnold R Kriegstein
Cite
Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity
The neocortex of primates, including humans, contains more abundant and diverse inhibitory neurons compared with rodents, but the …
Chandrasekhar S Raju
,
Julien Spatazza
,
Amelia Stanco
,
Phillip Larimer
,
Shawn F Sorrells
,
Kevin W Kelley
,
Cory R Nicholas
,
Mercedes F Paredes
,
Jan H Lui
,
Andrea R Hasenstaub
,
Arnold R Kriegstein
,
Arturo Alvarez-Buylla
,
John L Rubenstein
,
Michael C Oldham
Cite
An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder
Genomic association studies of common or rare protein-coding variation have established robust statistical approaches to account for …
Donna M Werling
,
Harrison Brand
,
Joon-Yong An
,
Matthew R Stone
,
Lingxue Zhu
,
Joseph T Glessner
,
Ryan L Collins
,
Shan Dong
,
Ryan M Layer
,
Eirene Markenscoff-Papadimitriou
,
Andrew Farrell
,
Grace B Schwartz
,
Harold Z Wang
,
Benjamin B Currall
,
Xuefang Zhao
,
Jeanselle Dea
,
Clif Duhn
,
Carolyn A Erdman
,
Michael C Gilson
,
Rachita Yadav
,
Robert E Handsaker
,
Seva Kashin
,
Lambertus Klei
,
Jeffrey D Mandell
,
Tomasz J Nowakowski
,
Yuwen Liu
,
Sirisha Pochareddy
,
Louw Smith
,
Michael F Walker
,
Matthew J Waterman
,
Xin He
,
Arnold R Kriegstein
,
John L Rubenstein
,
Nenad Sestan
,
Steven A McCarroll
,
Benjamin M Neale
,
Hilary Coon
,
A Jeremy Willsey
,
Jose Buxbaum
,
Mark J Daly
,
Matthew W State
,
Aaron R Quinlan
,
Gabor T Marth
,
Kathryn Roeder
,
Bernie Devlin
,
Michael E Talkowski
,
Stephan J Sanders
Cite
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
New neurons continue to be generated in the subgranular zone of the dentate gyrus of the adult mammalian hippocampus. This process has …
Shawn F Sorrells
,
Mercedes F Paredes
,
Arantxa Cebrian-Silla
,
Kadellyn Sandoval
,
Dashi Qi
,
Kevin W Kelley
,
David James
,
Simone Mayer
,
Julia Chang
,
Kurtis I Auguste
,
Edward F Chang
,
Antonio J Gutierrez
,
Arnold R Kriegstein
,
Gary W Mathern
,
Michael C Oldham
,
Eric J Huang
,
Jose Manuel Garcia-Verdugo
,
Zhengang Yang
,
Arturo Alvarez-Buylla
Cite
Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex
Systematic analyses of spatiotemporal gene expression trajectories during organogenesis have been challenging because diverse cell …
Tomasz J Nowakowski
,
Aparna Bhaduri
,
Alex A Pollen
,
Beatriz Alvarado
,
Mohammed A Mostajo-Radji
,
Elizabeth Di Lullo
,
Maximilian Haeussler
,
Carmen Sandoval Espinosa
,
Siyuan John Liu
,
Dmitry Velmeshev
,
Johain Ryad Ounadjela
,
Joe Shuga
,
Xiaohui Wang
,
Daniel A Lim
,
Jay A West
,
Anne A Leyrat
,
W James Kent
,
Arnold R Kriegstein
Cite
Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment
BACKGROUND: Tumor-associated macrophages (TAMs) are abundant in gliomas and immunosuppressive TAMs are a barrier to emerging …
Sören Müller
,
Gary Kohanbash
,
S John Liu
,
Beatriz Alvarado
,
Diego Carrera
,
Aparna Bhaduri
,
Payal B Watchmaker
,
Garima Yagnik
,
Elizabeth Di Lullo
,
Martina Malatesta
,
Nduka M Amankulor
,
Arnold R Kriegstein
,
Daniel A Lim
,
Manish Aghi
,
Hideho Okada
,
Aaron Diaz
Cite
The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas
A comprehensive characterization of neuronal cell types, their distributions, and patterns of connectivity is critical for …
Joseph R Ecker
,
Daniel H Geschwind
,
Arnold R Kriegstein
,
John Ngai
,
Pavel Osten
,
Damon Polioudakis
,
Aviv Regev
,
Nenad Sestan
,
Ian R Wickersham
,
Hongkui Zeng
Cite
The use of brain organoids to investigate neural development and disease
Understanding the development and dysfunction of the human brain is a major goal of neurobiology. Much of our current understanding of …
Elizabeth Di Lullo
,
Arnold R Kriegstein
Cite
Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia
Classical lissencephaly is a genetic neurological disorder associated with mental retardation and intractable epilepsy, and …
Marina Bershteyn
,
Tomasz J Nowakowski
,
Alex A Pollen
,
Elizabeth Di Lullo
,
Aishwarya Nene
,
Anthony Wynshaw-Boris
,
Arnold R Kriegstein
Cite
Dynamic behaviour of human neuroepithelial cells in the developing forebrain
To understand how diverse progenitor cells contribute to human neocortex development, we examined forebrain progenitor behaviour using …
Lakshmi Subramanian
,
Marina Bershteyn
,
Mercedes F Paredes
,
Arnold R Kriegstein
Cite
Zika virus cell tropism in the developing human brain and inhibition by azithromycin
The rapid spread of Zika virus (ZIKV) and its association with abnormal brain development constitute a global health emergency. …
Hanna Retallack
,
Elizabeth Di Lullo
,
Carolina Arias
,
Kristeene A Knopp
,
Matthew T Laurie
,
Carmen Sandoval Espinosa
,
Walter R Mancia Leon
,
Robert Krencik
,
Erik M Ullian
,
Julien Spatazza
,
Alex A Pollen
,
Caleigh Mandel-Brehm
,
Tomasz J Nowakowski
,
Arnold R Kriegstein
,
Joseph L DeRisi
Cite
Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas
Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor. Epidermal growth factor (EGF) and …
Sören Müller
,
Siyuan John Liu
,
Elizabeth Di Lullo
,
Martina Malatesta
,
Alex A Pollen
,
Tomasz J Nowakowski
,
Gary Kohanbash
,
Manish Aghi
,
Arnold R Kriegstein
,
Daniel A Lim
,
Aaron Diaz
Cite
Primate Neurons Flex Their Musclin
Sensory experience evokes long-lasting changes in neural circuits through activity-dependent gene expression. Ataman et al. (2016) …
Alex A Pollen
,
Arnold R Kriegstein
Cite
Transplanted Human Stem Cell-Derived Interneuron Precursors Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain after Spinal Cord Injury
Neuropathic pain and bladder dysfunction represent significant quality-of-life issues for many spinal cord injury patients. Loss of …
Thomas M Fandel
,
Alpa Trivedi
,
Cory R Nicholas
,
Haoqian Zhang
,
Jiadong Chen
,
Aida F Martinez
,
Linda J Noble-Haeusslein
,
Arnold R Kriegstein
Cite
Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development
The classic view of cortical development, embodied in the radial unit hypothesis, highlights the ventricular radial glia (vRG) scaffold …
Tomasz J Nowakowski
,
Alex A Pollen
,
Carmen Sandoval Espinosa
,
Arnold R Kriegstein
Cite
A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA
Long non-coding RNAs (lncRNAs) are a diverse and poorly conserved category of transcripts that have expanded greatly in primates, …
Neha Rani
,
Tomasz J Nowakowski
,
Hongjun Zhou
,
Sirie E Godshalk
,
Véronique Lisi
,
Arnold R Kriegstein
,
Kenneth S Kosik
Cite
Single-cell analysis of long non-coding RNAs in the developing human neocortex
BACKGROUND: Long non-coding RNAs (lncRNAs) comprise a diverse class of transcripts that can regulate molecular and cellular processes …
Siyuan John Liu
,
Tomasz J Nowakowski
,
Alex A Pollen
,
Jan H Lui
,
Max A Horlbeck
,
Frank J Attenello
,
Daniel He
,
Jonathan S Weissman
,
Arnold R Kriegstein
,
Aaron A Diaz
,
Daniel A Lim
Cite
Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells
The recent outbreak of Zika virus (ZIKV) in Brazil has been linked to substantial increases in fetal abnormalities and microcephaly. …
Tomasz J Nowakowski
,
Alex A Pollen
,
Elizabeth Di Lullo
,
Carmen Sandoval Espinosa
,
Marina Bershteyn
,
Arnold R Kriegstein
Cite
Neuronal Migration Dynamics in the Developing Ferret Cortex
During mammalian neocortical development, newborn excitatory and inhibitory neurons must migrate over long distances to reach their …
Caitlyn C Gertz
,
Arnold R Kriegstein
Cite
A GABAergic projection from the zona incerta to cortex promotes cortical neuron development
$γ$-Aminobutyric acid (GABA) is the major inhibitory transmitter in the mature brain but is excitatory in the developing cortex. We …
Jiadong Chen
,
Arnold R Kriegstein
Cite
Molecular identity of human outer radial glia during cortical development
Radial glia, the neural stem cells of the neocortex, are located in two niches: the ventricular zone and outer subventricular zone. …
Alex A Pollen
,
Tomasz J Nowakowski
,
Jiadong Chen
,
Hanna Retallack
,
Carmen Sandoval Espinosa
,
Cory R Nicholas
,
Joe Shuga
,
Siyuan John Liu
,
Michael C Oldham
,
Aaron Diaz
,
Daniel A Lim
,
Anne A Leyrat
,
Jay A West
,
Arnold R Kriegstein
Cite
Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons
The mammalian neocortex is composed of two major neuronal cell types with distinct origins: excitatory pyramidal neurons and inhibitory …
Corey C Harwell
,
Luis C Fuentealba
,
Adrian Gonzalez-Cerrillo
,
Phillip R L Parker
,
Caitlyn C Gertz
,
Emanuele Mazzola
,
Miguel Turrero Garcia
,
Arturo Alvarez-Buylla
,
Constance L Cepko
,
Arnold R Kriegstein
Cite
The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells
While thousands of long noncoding RNAs (lncRNAs) have been identified, few lncRNAs that control neural stem cell (NSC) behavior are …
Alexander D Ramos
,
Rebecca E Andersen
,
Siyuan John Liu
,
Tomasz Jan Nowakowski
,
Sung Jun Hong
,
Caitlyn Gertz
,
Ryan D Salinas
,
Hosniya Zarabi
,
Arnold R Kriegstein
,
Daniel A Lim
Cite
Radial glia in the proliferative ventricular zone of the embryonic and adult turtle, Trachemys scripta elegans
To better understand the role of radial glial (RG) cells in the evolution of the mammalian cerebral cortex, we investigated the role of …
Brian K Clinton
,
Christopher L Cunningham
,
Arnold R Kriegstein
,
Stephen C Noctor
,
Verónica Martı́nez-Cerdeño
Cite
Radial glia require PDGFD-PDGFR$β$ signalling in human but not mouse neocortex
Evolutionary expansion of the human neocortex underlies many of our unique mental abilities. This expansion has been attributed to the …
Jan H Lui
,
Tomasz J Nowakowski
,
Alex A Pollen
,
Ashkan Javaherian
,
Arnold R Kriegstein
,
Michael C Oldham
Cite
The Ink4a/Arf locus is a barrier to direct neuronal transdifferentiation
Non-neurogenic cell types, such as cortical astroglia and fibroblasts, can be directly converted into neurons by the overexpression of …
James D Price
,
Ki-Youb Park
,
Jiadong Chen
,
Ryan D Salinas
,
Mathew J Cho
,
Arnold R Kriegstein
,
Daniel A Lim
Cite
Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex
Large-scale surveys of single-cell gene expression have the potential to reveal rare cell populations and lineage relationships but …
Alex A Pollen
,
Tomasz J Nowakowski
,
Joe Shuga
,
Xiaohui Wang
,
Anne A Leyrat
,
Jan H Lui
,
Nianzhen Li
,
Lukasz Szpankowski
,
Brian Fowler
,
Peilin Chen
,
Naveen Ramalingam
,
Gang Sun
,
Myo Thu
,
Michael Norris
,
Ronald Lebofsky
,
Dominique Toppani
,
2nd, Darnell W Kemp
,
Michael Wong
,
Barry Clerkson
,
Brittnee N Jones
,
Shiquan Wu
,
Lawrence Knutsson
,
Beatriz Alvarado
,
Jing Wang
,
Lesley S Weaver
,
Andrew P May
,
Robert C Jones
,
Marc A Unger
,
Arnold R Kriegstein
,
Jay A A West
Cite
Control of outer radial glial stem cell mitosis in the human brain
Evolutionary expansion of the human neocortex is partially attributed to a relative abundance of neural stem cells in the fetal brain …
Bridget E L Ostrem
,
Jan H Lui
,
Caitlyn C Gertz
,
Arnold R Kriegstein
Cite
Interneurons from embryonic development to cell-based therapy
Many neurologic and psychiatric disorders are marked by imbalances between neural excitation and inhibition. In the cerebral cortex, …
Derek G Southwell
,
Cory R Nicholas
,
Allan I Basbaum
,
Michael P Stryker
,
Arnold R Kriegstein
,
John L Rubenstein
,
Arturo Alvarez-Buylla
Cite
Diverse behaviors of outer radial glia in developing ferret and human cortex
The dramatic increase in neocortical size and folding during mammalian brain evolution has been attributed to the elaboration of the …
Caitlyn C Gertz
,
Jan H Lui
,
Bridget E LaMonica
,
Xiaoqun Wang
,
Arnold R Kriegstein
Cite
The dynamics of neuronal migration
Proper lamination of the cerebral cortex is precisely orchestrated, especially when neurons migrate from their place of birth to their …
Qian Wu
,
Jing Liu
,
Ai Fang
,
Rui Li
,
Ye Bai
,
Arnold R Kriegstein
,
Xiaoqun Wang
Cite
Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells
Ring chromosomes are structural aberrations commonly associated with birth defects, mental disabilities and growth retardation. Rings …
Marina Bershteyn
,
Yohei Hayashi
,
Guillaume Desachy
,
Edward C Hsiao
,
Salma Sami
,
Kathryn M Tsang
,
Lauren A Weiss
,
Arnold R Kriegstein
,
Shinya Yamanaka
,
Anthony Wynshaw-Boris
Cite
Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences
GABAergic cortical interneurons underlie the complexity of neural circuits and are particularly numerous and diverse in humans. In …
David V Hansen
,
Jan H Lui
,
Pierre Flandin
,
Kazuaki Yoshikawa
,
John L Rubenstein
,
Arturo Alvarez-Buylla
,
Arnold R Kriegstein
Cite
Cerebral organoids in a dish: progress and prospects
A three-dimensional culture of cortical tissues derived from pluripotent stem cells offers an opportunity to model human brain …
Marina Bershteyn
,
Arnold R Kriegstein
Cite
Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex
The human neocortex is increased in size and complexity as compared with most other species. Neocortical expansion has recently been …
Bridget E LaMonica
,
Jan H Lui
,
David V Hansen
,
Arnold R Kriegstein
Cite
A high-resolution enhancer atlas of the developing telencephalon
The mammalian telencephalon plays critical roles in cognition, motor function, and emotion. Though many of the genes required for its …
Axel Visel
,
Leila Taher
,
Hani Girgis
,
Dalit May
,
Olga Golonzhka
,
Renee V Hoch
,
Gabriel L McKinsey
,
Kartik Pattabiraman
,
Shanni N Silberberg
,
Matthew J Blow
,
David V Hansen
,
Alex S Nord
,
Jennifer A Akiyama
,
Amy Holt
,
Roya Hosseini
,
Sengthavy Phouanenavong
,
Ingrid Plajzer-Frick
,
Malak Shoukry
,
Veena Afzal
,
Tommy Kaplan
,
Arnold R Kriegstein
,
Edward M Rubin
,
Ivan Ovcharenko
,
Len A Pennacchio
,
John L R Rubenstein
Cite
Regulation of microtubule stability and organization by mammalian Par3 in specifying neuronal polarity
Polarization of mammalian neurons with a specified axon requires precise regulation of microtubule and actin dynamics in the developing …
She Chen
,
Jia Chen
,
Hang Shi
,
Michelle Wei
,
David R Castaneda-Castellanos
,
Ronald S Bultje
,
Xin Pei
,
Arnold R Kriegstein
,
Mingjie Zhang
,
Song-Hai Shi
Cite
Stem cells in the land of the rising sun: ISSCR 2012
The 2012 annual meeting of the International Society for Stem Cell Research (ISSCR) marked the Tenth Anniversary of the ISSCR. Held in …
Kathrin Plath
,
Deepak Srivastava
,
Arturo Alvarez-Buylla
,
Elly M Tanaka
,
Arnold R Kriegstein
Cite
SnapShot: cortical development
Mollie B Woodworth
,
Luciano Custo Greig
,
Arnold R Kriegstein
,
Jeffrey D Macklis
Cite
OSVZ progenitors in the human cortex: an updated perspective on neurodevelopmental disease
Recent discoveries concerning the architecture and cellular dynamics of the developing human brain are revealing new differences …
Bridget E LaMonica
,
Jan H Lui
,
Xiaoqun Wang
,
Arnold R Kriegstein
Cite
Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation
The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that …
Corey C Harwell
,
Philip R L Parker
,
Steven M Gee
,
Ami Okada
,
Susan K McConnell
,
Anatol C Kreitzer
,
Arnold R Kriegstein
Cite
Orienting fate: spatial regulation of neurogenic divisions
Cleavage plane orientation has been thought to govern the fate of neural stem cell progeny, but supporting evidence in the neocortex …
Xiaoqun Wang
,
Jan H Lui
,
Arnold R Kriegstein
Cite
Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity
Neural stem cells (NSCs) persist in the subventricular zone (SVZ) of the adult brain. Location within this germinal region determines …
Rebecca A Ihrie
,
Jugal K Shah
,
Corey C Harwell
,
Jacob H Levine
,
Cristina D Guinto
,
Melissa Lezameta
,
Arnold R Kriegstein
,
Arturo Alvarez-Buylla
Cite
Development and evolution of the human neocortex
The size and surface area of the mammalian brain are thought to be critical determinants of intellectual ability. Recent studies show …
Jan H Lui
,
David V Hansen
,
Arnold R Kriegstein
Cite
Deriving excitatory neurons of the neocortex from pluripotent stem cells
The human cerebral cortex is an immensely complex structure that subserves critical functions that can be disrupted in developmental …
David V Hansen
,
John L R Rubenstein
,
Arnold R Kriegstein
Cite
A new subtype of progenitor cell in the mouse embryonic neocortex
A hallmark of mammalian brain evolution is cortical expansion, which reflects an increase in the number of cortical neurons established …
Xiaoqun Wang
,
Jin-Wu Tsai
,
Bridget LaMonica
,
Arnold R Kriegstein
Cite
Developmental genetics of vertebrate glial-cell specification
Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous system. These cells have diverse roles in the …
David H Rowitch
,
Arnold R Kriegstein
Cite
Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells
Radial glial progenitor cells exhibit bidirectional cell cycle-dependent nuclear oscillations. The purpose and underlying mechanism of …
Jin-Wu Tsai
,
Wei-Nan Lian
,
Shahrnaz Kemal
,
Arnold R Kriegstein
,
Richard B Vallee
Cite
Blocking early GABA depolarization with bumetanide results in permanent alterations in cortical circuits and sensorimotor gating deficits
A high incidence of seizures occurs during the neonatal period when immature networks are hyperexcitable and susceptible to …
Doris D Wang
,
Arnold R Kriegstein
Cite
Connexin 43 mediates the tangential to radial migratory switch in ventrally derived cortical interneurons
The adult cerebral cortex is composed of excitatory and inhibitory neurons that arise from progenitor cells in disparate proliferative …
Laura A B Elias
,
Mark Turmaine
,
John G Parnavelas
,
Arnold R Kriegstein
Cite
Neurogenic radial glia in the outer subventricular zone of human neocortex
Neurons in the developing rodent cortex are generated from radial glial cells that function as neural stem cells. These epithelial …
David V Hansen
,
Jan H Lui
,
Philip R L Parker
,
Arnold R Kriegstein
Cite
Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats
We investigated a strategy to ameliorate the motor symptoms of rats that received 6-hydroxydopamine (6-OHDA) lesions, a rodent model of …
Verónica Martı́nez-Cerdeño
,
Stephen C Noctor
,
Ana Espinosa
,
Jeanelle Ariza
,
Philip Parker
,
Samantha Orasji
,
Marcel M Daadi
,
Krystof Bankiewicz
,
Arturo Alvarez-Buylla
,
Arnold R Kriegstein
Cite
Regenerative medicine: Cell reprogramming gets direct
Cory R Nicholas
,
Arnold R Kriegstein
Cite
Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex
Asymmetric cell division of radial glial progenitors produces neurons while allowing self-renewal; however, little is known about the …
Ronald S Bultje
,
David R Castaneda-Castellanos
,
Lily Yeh Jan
,
Yuh-Nung Jan
,
Arnold R Kriegstein
,
Song-Hai Shi
Cite
Commentary: the prospect of cell-based therapy for epilepsy
About 30% of patient with epilepsy do not respond to available antiepileptic drugs. In addition to seizure suppression, novel …
Arnold R Kriegstein
,
Asla Pitkänen
Cite
Defining the role of GABA in cortical development
Of the many signals in the developing nervous system, GABA (gamma-aminobutyric acid) has been shown to be one of the earliest …
Doris D Wang
,
Arnold R Kriegstein
Cite
Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development
The development of glutamatergic synapses involves changes in the number and type of receptors present at the postsynaptic density. To …
G M Elias
,
L A B Elias
,
P F Apostolides
,
A R Kriegstein
,
R A Nicoll
Cite
GABA regulates stem cell proliferation before nervous system formation
Doris D Wang
,
Arnold R Kriegstein
,
Yehezkel Ben-Ari
Cite
A time and a place for nkx2-1 in interneuron specification and migration
The homeobox transcription factor, Nkx2-1, plays multiple roles during forebrain development. Using restricted genetic ablation of …
Laura A B Elias
,
Gregory B Potter
,
Arnold R Kriegstein
Cite
Progenitors from the postnatal forebrain subventricular zone differentiate into cerebellar-like interneurons and cerebellar-specific astrocytes upon transplantation
Forebrain subventricular zone (SVZ) progenitor cells give rise to glia and olfactory bulb interneurons during early postnatal life in …
Ana Milosevic
,
Stephen C Noctor
,
Veronica Martinez-Cerdeno
,
Arnold R Kriegstein
,
James E Goldman
Cite
Manipulating midbrain stem cell self-renewal
In this issue of Cell Stem Cell, Falk and colleagues (Falk et al., 2008) demonstrate that differential responsiveness to TGF-beta …
Joseph J LoTurco
,
Arnold R Kriegstein
Cite
GABA regulates excitatory synapse formation in the neocortex via NMDA receptor activation
The development of a balance between excitatory and inhibitory synapses is a critical process in the generation and maturation of …
Doris D Wang
,
Arnold R Kriegstein
Cite
Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis
Neocortical precursor cells undergo symmetric and asymmetric divisions while producing large numbers of diverse cortical cell types. In …
Stephen C Noctor
,
Verónica Martı́nez-Cerdeño
,
Arnold R Kriegstein
Cite
Gap junctions: multifaceted regulators of embryonic cortical development
The morphological development of the cerebral cortex from a primitive neuroepithelium into a complex laminar structure underlying …
Laura A B Elias
,
Arnold R Kriegstein
Cite
Gap junction adhesion is necessary for radial migration in the neocortex
Radial glia, the neuronal stem cells of the embryonic cerebral cortex, reside deep within the developing brain and extend radial fibres …
Laura A B Elias
,
Doris D Wang
,
Arnold R Kriegstein
Cite
Cortical neurogenesis: transitioning from advances in the laboratory to cell-based therapies
Arnold R Kriegstein
Cite
Contribution of intermediate progenitor cells to cortical histogenesis
The mammalian cerebral cortex is the most cellularly complex structure in the animal kingdom. Almost all cortical neurons are produced …
Stephen C Noctor
,
Verónica Martı́nez-Cerdeño
,
Arnold R Kriegstein
Cite
Neural stem and progenitor cells in cortical development
Recent work has begun to identify neural stem and progenitor cells in the embryonic and adult brain, and is unravelling the mechanisms …
Stephen C Noctor
,
Veronica Martinez-Cerdeno
,
Arnold R Kriegstein
Cite
Estradiol stimulates progenitor cell division in the ventricular and subventricular zones of the embryonic neocortex
Two distinct populations of cerebral cortical progenitor cells that generate neurons during embryogenesis have been identified: radial …
Verónica Martı́nez-Cerdeño
,
Stephen C Noctor
,
Arnold R Kriegstein
Cite
Characterization of mice with targeted deletion of glycine receptor alpha 2
Glycine receptors are ligand-gated chloride channels that mediate inhibitory neurotransmission in the adult nervous system. During …
T L Young-Pearse
,
L Ivic
,
A R Kriegstein
,
C L Cepko
Cite
The role of intermediate progenitor cells in the evolutionary expansion of the cerebral cortex
The vertebrate cerebral cortex varies from the 3-layered dorsal cortex of reptiles to the 6-layered lissencephalic cortex …
Verónica Martı́nez-Cerdeño
,
Stephen C Noctor
,
Arnold R Kriegstein
Cite
Blind patch clamp recordings in embryonic and adult mammalian brain slices
To obtain electrophysiological recordings in brain slices, sophisticated and expensive pieces of equipment can be used. However, costly …
David R Castaneda-Castellanos
,
Alexander C Flint
,
Arnold R Kriegstein
Cite
A new era in the ethics of human embryonic stem cell research
Scientific progress in human embryonic stem cell (hESC) research and increased funding make it imperative to look ahead to the ethical …
Bernard Lo
,
Patricia Zettler
,
Marcelle I Cedars
,
Elena Gates
,
Arnold R Kriegstein
,
Michelle Oberman
,
Renee Reijo Pera
,
Richard M Wagner
,
Mary T Wuerth
,
Leslie E Wolf
,
Keith R Yamamoto
Cite
LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages
Mutations in the human LIS1 gene cause the smooth brain disease classical lissencephaly. To understand the underlying mechanisms, we …
Jin-Wu Tsai
,
Yu Chen
,
Arnold R Kriegstein
,
Richard B Vallee
Cite
GABA puts the brake on stem cells
Arnold R Kriegstein
Cite
Constructing circuits: neurogenesis and migration in the developing neocortex
Our knowledge of the proliferation, migration, and differentiation of neurons has changed dramatically over the last 10 years. Whereas …
Arnold R Kriegstein
Cite
Calcium waves propagate through radial glial cells and modulate proliferation in the developing neocortex
The majority of neurons in the adult neocortex are produced embryonically during a brief but intense period of neuronal proliferation. …
Tamily A Weissman
,
Patricio A Riquelme
,
Lidija Ivic
,
Alexander C Flint
,
Arnold R Kriegstein
Cite
Controlling neuron number: does Numb do the math?
David R Castaneda-Castellanos
,
Arnold R Kriegstein
Cite
Patterns of neuronal migration in the embryonic cortex
Real-time imaging of migrating neurons has changed our understanding of how newborn neurons reach their final positions in the …
Arnold R Kriegstein
,
Stephen C Noctor
Cite
Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
Precise patterns of cell division and migration are crucial to transform the neuroepithelium of the embryonic forebrain into the adult …
Stephen C Noctor
,
Verónica Martı́nez-Cerdeño
,
Lidija Ivic
,
Arnold R Kriegstein
Cite
Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors
Glycine and gamma-aminobutyric acid, type A (GABA(A)) receptors are members of the ligand-gated ion channel superfamily that mediate …
Lidija Ivic
,
Tristan T J Sands
,
Nathan Fishkin
,
Koji Nakanishi
,
Arnold R Kriegstein
,
Kristian Strømgaard
Cite
Radial glia diversity: a matter of cell fate
Early in development of the central nervous system, radial glial cells arise from the neuroepithelial cells lining the ventricles …
Arnold R Kriegstein
,
Magdalena Götz
Cite
Neurogenic radial glial cells in reptile, rodent and human: from mitosis to migration
Radial glial cells play at least two crucial roles in cortical development: neuronal production in the ventricular zone (VZ) and the …
Tamily Weissman
,
Stephen C Noctor
,
Brian K Clinton
,
Lawrence S Honig
,
Arnold R Kriegstein
Cite
Neurons from radial glia: the consequences of asymmetric inheritance
Recent work suggests that radial glial cells represent many, if not most, of the neuronal progenitors in the developing cortex. …
Gord Fishell
,
Arnold R Kriegstein
Cite
Developmental neurotransmitters?
Previous studies support an early role for neurotransmitter signaling before synaptogenesis, but puzzlingly, a neurological phenotype …
David F Owens
,
Arnold R Kriegstein
Cite
Is there more to GABA than synaptic inhibition?
In the mature brain, GABA (gamma-aminobutyric acid) functions primarily as an inhibitory neurotransmitter. But it can also act as a …
David F Owens
,
Arnold R Kriegstein
Cite
Increased excitability and decreased sensitivity to GABA in an animal model of dysplastic cortex
PURPOSE: Cortical dysplasia (CD) is associated with epilepsy in both the pediatric and adult populations. The mechanism underlying …
Ethan A Benardete
,
Arnold R Kriegstein
Cite
Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia
The embryonic ventricular zone (VZ) of the cerebral cortex contains migrating neurons, radial glial cells, and a large population of …
Stephen C Noctor
,
Alexander C Flint
,
Tamily A Weissman
,
Winston S Wong
,
Brian K Clinton
,
Arnold R Kriegstein
Cite
GABA may act as a self-limiting trophic factor at developing synapses
Early in development, synapses with glycine or gamma-aminobutyric acid (GABA)-gated chloride channels exhibit the ability to depolarize …
A R Kriegstein
,
D F Owens
Cite
Neurons derived from radial glial cells establish radial units in neocortex
The neocortex of the adult brain consists of neurons and glia that are generated by precursor cells of the embryonic ventricular zone. …
S C Noctor
,
A C Flint
,
T A Weissman
,
R S Dammerman
,
A R Kriegstein
Cite
Maturation of channels and receptors: consequences for excitability
D F Owens
,
A R Kriegstein
Cite
Transient actions of neurotransmitters during neocortical development
R S Dammerman
,
A R Kriegstein
Cite
Extrinsic GABAergic innervation of developing neocortical layer 1 in organotypic slice co-cultures
Afferents from the zona incerta (ZI) of the ventral thalamus contribute to the dense, transient gamma-aminobutyric acid (GABA)ergic …
R S Dammerman
,
S C Noctor
,
A R Kriegstein
Cite
An excitatory GABAergic plexus in developing neocortical layer 1
Layer 1 of the developing rodent somatosensory cortex contains a dense, transient GABAergic fiber plexus. Axons arising from the zona …
R S Dammerman
,
A C Flint
,
S Noctor
,
A R Kriegstein
Cite
Calcium dynamics of neocortical ventricular zone cells
Cell-cell signaling within the neocortical ventricular zone (VZ) has been shown to influence the proliferation of VZ precursor cells …
D F Owens
,
A C Flint
,
R S Dammerman
,
A R Kriegstein
Cite
Leukoencephalopathy and raised brain lactate from heroin vapor inhalation (``chasing the dragon'')
BACKGROUND: Inhalation of heated heroin vapor (``chasing the dragon’’), which is gaining popularity among drug users …
A R Kriegstein
,
D C Shungu
,
W S Millar
,
B A Armitage
,
J C Brust
,
S Chillrud
,
J Goldman
,
T Lynch
Cite
Endogenous activation of metabotropic glutamate receptors in neocortical development causes neuronal calcium oscillations
Oscillations in intracellular free calcium concentration (
Ca(2+)
) occur spontaneously in immature neurons of the developing cerebral …
A C Flint
,
R S Dammerman
,
A R Kriegstein
Cite
Changing properties of GABA(A) receptor-mediated signaling during early neocortical development
Evidence from several brain regions suggests gamma-aminobutyric acid (GABA) can exert a trophic influence during development, expanding …
D F Owens
,
X Liu
,
A R Kriegstein
Cite
Ontogeny of channels, transmitters and epileptogenesis
A R Kriegstein
,
D F Owens
,
M Avoli
Cite
Patterns of intracellular calcium fluctuation in precursor cells of the neocortical ventricular zone
Changes in intracellular free calcium concentration ([Ca2+]i) are known to influence a variety of events in developing neurons. …
D F Owens
,
A R Kriegstein
Cite
Nonsynaptic glycine receptor activation during early neocortical development
Glycine receptors (GlyRs) contribute to fast inhibitory synaptic transmission in the brain stem and spinal cord. GlyR subunits are …
A C Flint
,
X Liu
,
A R Kriegstein
Cite
Postnatal development of low [Mg2+] oscillations in neocortex
One form of rhythmic activity intrinsic to neocortex can be induced in slices of adult somatosensory cortex by lowering [Mg2+]o to …
A C Flint
,
U S Maisch
,
A R Kriegstein
Cite
Cell coupling and uncoupling in the ventricular zone of developing neocortex
Cells within the ventricular zone (VZ) of developing neocortex are coupled together into clusters by gap junction channels. The …
K Bittman
,
D F Owens
,
A R Kriegstein
,
J J LoTurco
Cite
NR2A subunit expression shortens NMDA receptor synaptic currents in developing neocortex
NMDA receptors play important roles in learning and memory and in sculpting neural connections during development. After the period of …
A C Flint
,
U S Maisch
,
J H Weishaupt
,
A R Kriegstein
,
H Monyer
Cite
Mechanisms underlying neuronal migration disorders and epilepsy
Neuronal migration disorders are often associated with intractable epilepsy. These cortical malformations are quite heterogeneous, …
A C Flint
,
A R Kriegstein
Cite
Heroin inhalation and progressive spongiform leukoencephalopathy
A R Kriegstein
,
B A Armitage
,
P Y Kim
Cite
Excitatory GABA responses in embryonic and neonatal cortical slices demonstrated by gramicidin perforated-patch recordings and calcium imaging
Gramicidin perforated-patch-clamp recordings in brain slices were used to obtain an accurate assessment of the developmental change in …
D F Owens
,
L H Boyce
,
M B Davis
,
A R Kriegstein
Cite
Cortical neurogenesis and its disorders
Proliferative cells lining the cerebral ventricles generate all of the phenotypically diverse neurons of the adult cortex. Recent …
A R Kriegstein
Cite
GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis
We have found that, during the early stages of cortical neurogenesis, both GABA and glutamate depolarize cells in the ventricular zone …
J J LoTurco
,
D F Owens
,
M J Heath
,
M B Davis
,
A R Kriegstein
Cite
Properties of amino acid neurotransmitter receptors of embryonic cortical neurons when activated by exogenous and endogenous agonists
The properties of receptors for amino acid neurotransmitters expressed by developing cortical neurons were studied with the use of …
M G Blanton
,
A R Kriegstein
Cite
Abnormal action-potential bursts and synchronized, GABA-mediated inhibitory potentials in an in vitro model of focal epilepsy
Focal, freeze-induced lesions were made in isolated hemispheres of turtle cerebral cortex in vitro, permitting the investigation of …
M D Troyer
,
M G Blanton
,
A R Kriegstein
Cite
Norepinephrine activates potassium conductance in neurons of the turtle cerebral cortex
Whole-cell voltage and current clamp recordings were obtained from cortical neurons of the pond turtle, Pseudemys scripta elegans. …
K J Blanton
,
A R Kriegstein
Cite
Spontaneous action potential activity and synaptic currents in the embryonic turtle cerebral cortex
We used loose-patch and whole-cell recording techniques to study the development of spontaneous action potential activity and …
M G Blanton
,
A R Kriegstein
Cite
Morphological differentiation of distinct neuronal classes in embryonic turtle cerebral cortex
As a starting point for understanding the development of the cerebral cortex in reptiles and for determining how reptilian cortical …
M G Blanton
,
A R Kriegstein
Cite
Appearance of putative amino acid neurotransmitters during differentiation of neurons in embryonic turtle cerebral cortex
Pyramidal and nonpyramidal neurons can be recognized early in the development of the cerebral cortex in both reptiles and mammals, and …
M G Blanton
,
A R Kriegstein
Cite
Clusters of coupled neuroblasts in embryonic neocortex
The neocortex of the brain develops from a simple germinal layer into a complex multilayer structure. To investigate cellular …
J J Lo Turco
,
A R Kriegstein
Cite
Initial expression and endogenous activation of NMDA channels in early neocortical development
We have made patch-clamp recordings from slices of fetal and postnatal rat neocortex in order to study the initial expression and …
J J LoTurco
,
M G Blanton
,
A R Kriegstein
Cite
Turtle cortical neurons survive glutamate exposures that are lethal to mammalian neurons
Glutamate is an excitatory neurotransmitter in turtle and mammalian cortex. In high concentrations it is toxic to mammalian neurons and …
A M Wilson
,
A R Kriegstein
Cite
Endogenous neurotransmitter activates N-methyl-D-aspartate receptors on differentiating neurons in embryonic cortex
Before synapses form in embryonic turtle cerebral cortex, an endogenous neurotransmitter activates N-methyl-D-aspartate (NMDA) channels …
M G Blanton
,
J J Lo Turco
,
A R Kriegstein
Cite
Differential activation of glutamate receptors by spontaneously released transmitter in slices of neocortex
Whole-cell recordings were made from neurons in neocortical brain slices in order to characterize excitatory synaptic currents mediated …
J J LoTurco
,
I Mody
,
A R Kriegstein
Cite
Whole cell recording from neurons in slices of reptilian and mammalian cerebral cortex
We describe methods for obtaining stable, whole-cell recordings from neurons in brain hemispheres from turtles and in brain slices from …
M G Blanton
,
J J Lo Turco
,
A R Kriegstein
Cite
The development of bicuculline-induced epileptiform discharges in embryonic turtle cortex
The appearance of bicuculline-induced epileptiform discharges was studied in embryonic turtle cortex using extracellular recording …
J M Shen
,
A R Kriegstein
Cite
Development of GABA responsiveness in embryonic turtle cortical neurons
The whole-cell patch-clamp method was used to study the development of functional GABA receptors in cortical neurons dissociated from …
J M Shen
,
J R Huguenard
,
A R Kriegstein
Cite
Quantitative autoradiography of muscarinic and benzodiazepine receptors in the forebrain of the turtle, Pseudemys scripta
The distribution of muscarinic and benzodiazepine receptors was investigated in the turtle forebrain by the technique of in vitro …
J R Schlegel
,
A R Kriegstein
Cite
Synaptic responses of cortical pyramidal neurons to light stimulation in the isolated turtle visual system
The resistance of the turtle brain to hypoxic injury permits a unique in vitro preparation in which the organization and function of …
A R Kriegstein
Cite
Cellular and synaptic physiology and epileptogenesis of developing rat neocortical neurons in vitro
The cellular and synaptic physiology of developing rat neocortical neurons was studied using the in vitro slice method. Rats aged 1-28 …
A R Kriegstein
,
T Suppes
,
D A Prince
Cite
Evidence for the inhibitory neurotransmitter gamma-aminobutyric acid in aspiny and sparsely spiny nonpyramidal neurons of the turtle dorsal cortex
In order to learn more about the anatomical substrate for gamma-aminobutyric acid (GABA)-mediated inhibition in cortical structures, …
M G Blanton
,
J M Shen
,
A R Kriegstein
Cite
Glutamate neurotoxicity in cortical cell culture
The central neurotoxicity of the excitatory amino acid neurotransmitter glutamate has been postulated to participate in the …
D W Choi
,
M Maulucci-Gedde
,
A R Kriegstein
Cite
Turtle hippocampal cortex contains distinct cell types, burst-firing neurons, and an epileptogenic subfield
The dorsal and medial telencephalon of reptiles consists of a simple trilaminar cortex. The turtle dorsal cortex has been identified as …
J M Shen
,
A R Kriegstein
Cite
Monoclonal antibodies to the turtle cortex reveal neuronal subsets, antigenic cross-reactivity with the mammalian neocortex, and forebrain structures sharing a pallial derivation
The dorsal cortex of the pond turtle (Pseudemys scripta) is a relatively simple structure consisting of two principal classes of …
A R Kriegstein
,
J M Shen
,
N Eshhar
Cite
Cellular physiology of the turtle visual cortex: synaptic properties and intrinsic circuitry
We have examined the synaptic physiology of the isolated dorsal cortex of the turtle, Pseudemys scripta elegans. Electrical stimulation …
A R Kriegstein
,
B W Connors
Cite
Cellular physiology of the turtle visual cortex: distinctive properties of pyramidal and stellate neurons
The electrophysiological properties of neurons in the three-layered dorsal cortex of the turtle, Pseudemys scripta elegans, have been …
B W Connors
,
A R Kriegstein
Cite
The influence of dopamine on epileptiform burst activity in hippocampal pyramidal neurons
Dopamine (DA) application to guinea pig hippocampal CA1 neurons in vitro causes hyperpolarization of the resting potential, increase in …
T Suppes
,
A R Kriegstein
,
D A Prince
Cite
Morphological classification of rat cortical neurons in cell culture
Neurons in ``mature’’ (4- to 6-week-old) dissociated cell cultures of 15-day gestational age rat fetal cortex were injected …
A R Kriegstein
,
M A Dichter
Cite
Cholinergic enhancement of penicillin-induced epileptiform discharges in pyramidal neurons of the guinea pig hippocampus
Acetylcholine (1-20 mM) was applied to guinea pig hippocampal slices bathed in normal and penicillin-containing media. Recordings in …
A R Kriegstein
,
T Suppes
,
D A Prince
Cite
Neurology-important advances in clinical medicine: treatment of febrile convulsions
A R Kriegstein
Cite
Stages in the post-hatching development of Aplysia californica
In order to study the development of the nervous system of the marine mollusc, Aplysia californica, it is necessary objectively to …
A R Kriegstein
Cite
Development of the nervous system of Aplysia californica
The ability to grow the marine molluse Aplysia under laboratory conditions allows a detailed study of the formation of the nervous …
A R Kriegstein
Cite
Metamorphosis of Aplysia californica in laboratory culture
To utilize the advantages offered by the large identified nerve cells of the marine mollusc Aplysia californica for cellular biological …
A R Kriegstein
,
V Castellucci
,
E R Kandel
Cite
Cite
×