Publications

How mechanisms of stem cell polarity shape the human cerebral cortex
Apical-basal progenitor cell polarity establishes key features of the radial and laminar architecture of the developing human cortex. …
Cite
Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain
Interactions between angiogenesis and neurogenesis regulate embryonic brain development. However, a comprehensive understanding of the …
Cite
A nomenclature consensus for nervous system organoids and assembloids
Self-organizing three-dimensional cellular models derived from human pluripotent stem cells or primary tissue have great potential to …
Cite
Zika virus alters centrosome organization to suppress the innate immune response
Zika virus (ZIKV) is a flavivirus transmitted via mosquitoes and sex to cause congenital neurodevelopmental defects, including …
Cite
Tropism of SARS-CoV-2 for human cortical astrocytes
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) readily infects a variety of cell types impacting the function of …
Cite
Identification of Lipid Heterogeneity and Diversity in the Developing Human Brain
The lipidome is currently understudied but fundamental to life. Within the brain, little is known about cell-type lipid heterogeneity, …
Cite
An atlas of cortical arealization identifies dynamic molecular signatures
The human brain is subdivided into distinct anatomical structures, including the neocortex, which in turn encompasses dozens of …
Cite
Distinct nuclear compartment-associated genome architecture in the developing mammalian brain
Nuclear compartments are thought to play a role in three-dimensional genome organization and gene expression. In mammalian brain, the …
Cite
Human intermediate progenitor diversity during cortical development
Studies of the spatiotemporal, transcriptomic, and morphological diversity of radial glia (RG) have spurred our current models of human …
Cite
Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia
The human cortex comprises diverse cell types that emerge from an initially uniform neuroepithelium that gives rise to radial glia, the …
Cite
Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) readily infects a variety of cell types impacting the function of …
Cite
Cell-type-specific 3D epigenomes in the developing human cortex
Lineage-specific epigenomic changes during human corticogenesis have been difficult to study owing to challenges with sample …
Cite
Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies
CD19-directed immunotherapies are clinically effective for treating B cell malignancies but also cause a high incidence of …
Cite
mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex
Outer radial glial (oRG) cells are a population of neural stem cells prevalent in the developing human cortex that contribute to its …
Cite
Are Organoids Ready for Prime Time?
Innovations in organoid-based models of human tissues have made them an exciting experimental platform for studying development and …
Cite
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency
Aberrant aggregation of the RNA-binding protein TDP-43 in neurons is a hallmark of frontotemporal lobar degeneration caused by …
Cite
Origins and Proliferative States of Human Oligodendrocyte Precursor Cells
Human cerebral cortex size and complexity has increased greatly during evolution. While increased progenitor diversity and enhanced …
Cite
A Chromatin Accessibility Atlas of the Developing Human Telencephalon
To discover regulatory elements driving the specificity of gene expression in different cell types and regions of the developing human …
Cite
Identification of amygdala-expressed genes associated with autism spectrum disorder
BACKGROUND: Studies of individuals with autism spectrum disorder (ASD) have revealed a strong multigenic basis with the identification …
Cite
SMART-Q: An Integrative Pipeline Quantifying Cell Type-Specific RNA Transcription
Accurate RNA quantification at the single-cell level is critical for understanding the dynamics of gene expression and regulation …
Cite
Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog
Neural stem cells (NSCs) in the prenatal neocortex progressively generate different subtypes of glutamatergic projection neurons. …
Cite
Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma
Glioblastoma is a devastating form of brain cancer. To identify aspects of tumor heterogeneity that may illuminate drivers of tumor …
Cite
Cell stress in cortical organoids impairs molecular subtype specification
Cortical organoids are self-organizing three-dimensional cultures that model features of the developing human cerebral cortex(1,2). …
Cite
Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation
Pelizaeus-Merzbacher disease (PMD) is an X-linked leukodystrophy caused by mutations in Proteolipid Protein 1 (PLP1), encoding a major …
Cite
Neuroglial stem cell-derived inflammatory pseudotumor (n-SCIPT): clinicopathologic characterization of a novel lesion of the lumbosacral spinal cord and nerve roots following intrathecal allogeneic stem cell intervention
Cite
Neuronal vulnerability and multilineage diversity in multiple sclerosis
Multiple sclerosis (MS) is a neuroinflammatory disease with a relapsing-remitting disease course at early stages, distinct lesion …
Cite
Immature excitatory neurons develop during adolescence in the human amygdala
The human amygdala grows during childhood, and its abnormal development is linked to mood disorders. The primate amygdala contains a …
Cite
Single-cell genomics identifies cell type-specific molecular changes in autism
Despite the clinical and genetic heterogeneity of autism, bulk gene expression studies show that changes in the neocortex of autism …
Cite
Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex
In the developing human neocortex, progenitor cells generate diverse cell types prenatally. Progenitor cells and newborn neurons …
Cite
Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution
Direct comparisons of human and non-human primate brains can reveal molecular pathways underlying remarkable specializations of the …
Cite
Neuroserpin expression during human brain development and in adult brain revealed by immunohistochemistry and single cell RNA sequencing
Neuroserpin is a serine-protease inhibitor mainly expressed in the CNS and involved in the inhibition of the proteolytic cascade. …
Cite
Does Adult Neurogenesis Persist in the Human Hippocampus?
Cite
Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development
MicroRNAs (miRNAs) regulate many cellular events during brain development by interacting with hundreds of mRNA transcripts. However, …
Cite
Identification of cell types in a mouse brain single-cell atlas using low sampling coverage
BACKGROUND: High throughput methods for profiling the transcriptomes of single cells have recently emerged as transformative approaches …
Cite
Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity
The neocortex of primates, including humans, contains more abundant and diverse inhibitory neurons compared with rodents, but the …
Cite
An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder
Genomic association studies of common or rare protein-coding variation have established robust statistical approaches to account for …
Cite
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
New neurons continue to be generated in the subgranular zone of the dentate gyrus of the adult mammalian hippocampus. This process has …
Cite
Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex
Systematic analyses of spatiotemporal gene expression trajectories during organogenesis have been challenging because diverse cell …
Cite
Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment
BACKGROUND: Tumor-associated macrophages (TAMs) are abundant in gliomas and immunosuppressive TAMs are a barrier to emerging …
Cite
The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas
A comprehensive characterization of neuronal cell types, their distributions, and patterns of connectivity is critical for …
Cite
The use of brain organoids to investigate neural development and disease
Understanding the development and dysfunction of the human brain is a major goal of neurobiology. Much of our current understanding of …
Cite
Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia
Classical lissencephaly is a genetic neurological disorder associated with mental retardation and intractable epilepsy, and …
Cite
Dynamic behaviour of human neuroepithelial cells in the developing forebrain
To understand how diverse progenitor cells contribute to human neocortex development, we examined forebrain progenitor behaviour using …
Cite
Zika virus cell tropism in the developing human brain and inhibition by azithromycin
The rapid spread of Zika virus (ZIKV) and its association with abnormal brain development constitute a global health emergency. …
Cite
Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas
Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor. Epidermal growth factor (EGF) and …
Cite
Primate Neurons Flex Their Musclin
Sensory experience evokes long-lasting changes in neural circuits through activity-dependent gene expression. Ataman et al. (2016) …
Cite
Transplanted Human Stem Cell-Derived Interneuron Precursors Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain after Spinal Cord Injury
Neuropathic pain and bladder dysfunction represent significant quality-of-life issues for many spinal cord injury patients. Loss of …
Cite
Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development
The classic view of cortical development, embodied in the radial unit hypothesis, highlights the ventricular radial glia (vRG) scaffold …
Cite
A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA
Long non-coding RNAs (lncRNAs) are a diverse and poorly conserved category of transcripts that have expanded greatly in primates, …
Cite
Single-cell analysis of long non-coding RNAs in the developing human neocortex
BACKGROUND: Long non-coding RNAs (lncRNAs) comprise a diverse class of transcripts that can regulate molecular and cellular processes …
Cite
Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells
The recent outbreak of Zika virus (ZIKV) in Brazil has been linked to substantial increases in fetal abnormalities and microcephaly. …
Cite
Neuronal Migration Dynamics in the Developing Ferret Cortex
During mammalian neocortical development, newborn excitatory and inhibitory neurons must migrate over long distances to reach their …
Cite
A GABAergic projection from the zona incerta to cortex promotes cortical neuron development
$γ$-Aminobutyric acid (GABA) is the major inhibitory transmitter in the mature brain but is excitatory in the developing cortex. We …
Cite
Molecular identity of human outer radial glia during cortical development
Radial glia, the neural stem cells of the neocortex, are located in two niches: the ventricular zone and outer subventricular zone. …
Cite
Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons
The mammalian neocortex is composed of two major neuronal cell types with distinct origins: excitatory pyramidal neurons and inhibitory …
Cite
The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells
While thousands of long noncoding RNAs (lncRNAs) have been identified, few lncRNAs that control neural stem cell (NSC) behavior are …
Cite
Radial glia in the proliferative ventricular zone of the embryonic and adult turtle, Trachemys scripta elegans
To better understand the role of radial glial (RG) cells in the evolution of the mammalian cerebral cortex, we investigated the role of …
Cite
Radial glia require PDGFD-PDGFR$β$ signalling in human but not mouse neocortex
Evolutionary expansion of the human neocortex underlies many of our unique mental abilities. This expansion has been attributed to the …
Cite
The Ink4a/Arf locus is a barrier to direct neuronal transdifferentiation
Non-neurogenic cell types, such as cortical astroglia and fibroblasts, can be directly converted into neurons by the overexpression of …
Cite
Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex
Large-scale surveys of single-cell gene expression have the potential to reveal rare cell populations and lineage relationships but …
Cite
Control of outer radial glial stem cell mitosis in the human brain
Evolutionary expansion of the human neocortex is partially attributed to a relative abundance of neural stem cells in the fetal brain …
Cite
Interneurons from embryonic development to cell-based therapy
Many neurologic and psychiatric disorders are marked by imbalances between neural excitation and inhibition. In the cerebral cortex, …
Cite
Diverse behaviors of outer radial glia in developing ferret and human cortex
The dramatic increase in neocortical size and folding during mammalian brain evolution has been attributed to the elaboration of the …
Cite
The dynamics of neuronal migration
Proper lamination of the cerebral cortex is precisely orchestrated, especially when neurons migrate from their place of birth to their …
Cite
Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells
Ring chromosomes are structural aberrations commonly associated with birth defects, mental disabilities and growth retardation. Rings …
Cite
Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences
GABAergic cortical interneurons underlie the complexity of neural circuits and are particularly numerous and diverse in humans. In …
Cite
Cerebral organoids in a dish: progress and prospects
A three-dimensional culture of cortical tissues derived from pluripotent stem cells offers an opportunity to model human brain …
Cite
Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex
The human neocortex is increased in size and complexity as compared with most other species. Neocortical expansion has recently been …
Cite
A high-resolution enhancer atlas of the developing telencephalon
The mammalian telencephalon plays critical roles in cognition, motor function, and emotion. Though many of the genes required for its …
Cite
Regulation of microtubule stability and organization by mammalian Par3 in specifying neuronal polarity
Polarization of mammalian neurons with a specified axon requires precise regulation of microtubule and actin dynamics in the developing …
Cite
Stem cells in the land of the rising sun: ISSCR 2012
The 2012 annual meeting of the International Society for Stem Cell Research (ISSCR) marked the Tenth Anniversary of the ISSCR. Held in …
Cite
SnapShot: cortical development
Cite
OSVZ progenitors in the human cortex: an updated perspective on neurodevelopmental disease
Recent discoveries concerning the architecture and cellular dynamics of the developing human brain are revealing new differences …
Cite
Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation
The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that …
Cite
Orienting fate: spatial regulation of neurogenic divisions
Cleavage plane orientation has been thought to govern the fate of neural stem cell progeny, but supporting evidence in the neocortex …
Cite
Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity
Neural stem cells (NSCs) persist in the subventricular zone (SVZ) of the adult brain. Location within this germinal region determines …
Cite
Development and evolution of the human neocortex
The size and surface area of the mammalian brain are thought to be critical determinants of intellectual ability. Recent studies show …
Cite
Deriving excitatory neurons of the neocortex from pluripotent stem cells
The human cerebral cortex is an immensely complex structure that subserves critical functions that can be disrupted in developmental …
Cite
A new subtype of progenitor cell in the mouse embryonic neocortex
A hallmark of mammalian brain evolution is cortical expansion, which reflects an increase in the number of cortical neurons established …
Cite
Developmental genetics of vertebrate glial-cell specification
Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous system. These cells have diverse roles in the …
Cite
Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells
Radial glial progenitor cells exhibit bidirectional cell cycle-dependent nuclear oscillations. The purpose and underlying mechanism of …
Cite
Blocking early GABA depolarization with bumetanide results in permanent alterations in cortical circuits and sensorimotor gating deficits
A high incidence of seizures occurs during the neonatal period when immature networks are hyperexcitable and susceptible to …
Cite
Connexin 43 mediates the tangential to radial migratory switch in ventrally derived cortical interneurons
The adult cerebral cortex is composed of excitatory and inhibitory neurons that arise from progenitor cells in disparate proliferative …
Cite
Neurogenic radial glia in the outer subventricular zone of human neocortex
Neurons in the developing rodent cortex are generated from radial glial cells that function as neural stem cells. These epithelial …
Cite
Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats
We investigated a strategy to ameliorate the motor symptoms of rats that received 6-hydroxydopamine (6-OHDA) lesions, a rodent model of …
Cite
Regenerative medicine: Cell reprogramming gets direct
Cite
Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex
Asymmetric cell division of radial glial progenitors produces neurons while allowing self-renewal; however, little is known about the …
Cite
Commentary: the prospect of cell-based therapy for epilepsy
About 30% of patient with epilepsy do not respond to available antiepileptic drugs. In addition to seizure suppression, novel …
Cite
Defining the role of GABA in cortical development
Of the many signals in the developing nervous system, GABA (gamma-aminobutyric acid) has been shown to be one of the earliest …
Cite
Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development
The development of glutamatergic synapses involves changes in the number and type of receptors present at the postsynaptic density. To …
Cite
GABA regulates stem cell proliferation before nervous system formation
Cite
A time and a place for nkx2-1 in interneuron specification and migration
The homeobox transcription factor, Nkx2-1, plays multiple roles during forebrain development. Using restricted genetic ablation of …
Cite
Progenitors from the postnatal forebrain subventricular zone differentiate into cerebellar-like interneurons and cerebellar-specific astrocytes upon transplantation
Forebrain subventricular zone (SVZ) progenitor cells give rise to glia and olfactory bulb interneurons during early postnatal life in …
Cite
Manipulating midbrain stem cell self-renewal
In this issue of Cell Stem Cell, Falk and colleagues (Falk et al., 2008) demonstrate that differential responsiveness to TGF-beta …
Cite
GABA regulates excitatory synapse formation in the neocortex via NMDA receptor activation
The development of a balance between excitatory and inhibitory synapses is a critical process in the generation and maturation of …
Cite
Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis
Neocortical precursor cells undergo symmetric and asymmetric divisions while producing large numbers of diverse cortical cell types. In …
Cite
Gap junctions: multifaceted regulators of embryonic cortical development
The morphological development of the cerebral cortex from a primitive neuroepithelium into a complex laminar structure underlying …
Cite
Gap junction adhesion is necessary for radial migration in the neocortex
Radial glia, the neuronal stem cells of the embryonic cerebral cortex, reside deep within the developing brain and extend radial fibres …
Cite
Cortical neurogenesis: transitioning from advances in the laboratory to cell-based therapies
Cite
Contribution of intermediate progenitor cells to cortical histogenesis
The mammalian cerebral cortex is the most cellularly complex structure in the animal kingdom. Almost all cortical neurons are produced …
Cite
Neural stem and progenitor cells in cortical development
Recent work has begun to identify neural stem and progenitor cells in the embryonic and adult brain, and is unravelling the mechanisms …
Cite
Estradiol stimulates progenitor cell division in the ventricular and subventricular zones of the embryonic neocortex
Two distinct populations of cerebral cortical progenitor cells that generate neurons during embryogenesis have been identified: radial …
Cite
Characterization of mice with targeted deletion of glycine receptor alpha 2
Glycine receptors are ligand-gated chloride channels that mediate inhibitory neurotransmission in the adult nervous system. During …
Cite
The role of intermediate progenitor cells in the evolutionary expansion of the cerebral cortex
The vertebrate cerebral cortex varies from the 3-layered dorsal cortex of reptiles to the 6-layered lissencephalic cortex …
Cite
Blind patch clamp recordings in embryonic and adult mammalian brain slices
To obtain electrophysiological recordings in brain slices, sophisticated and expensive pieces of equipment can be used. However, costly …
Cite
A new era in the ethics of human embryonic stem cell research
Scientific progress in human embryonic stem cell (hESC) research and increased funding make it imperative to look ahead to the ethical …
Cite
LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages
Mutations in the human LIS1 gene cause the smooth brain disease classical lissencephaly. To understand the underlying mechanisms, we …
Cite
GABA puts the brake on stem cells
Cite
Constructing circuits: neurogenesis and migration in the developing neocortex
Our knowledge of the proliferation, migration, and differentiation of neurons has changed dramatically over the last 10 years. Whereas …
Cite
Calcium waves propagate through radial glial cells and modulate proliferation in the developing neocortex
The majority of neurons in the adult neocortex are produced embryonically during a brief but intense period of neuronal proliferation. …
Cite
Controlling neuron number: does Numb do the math?
Cite
Patterns of neuronal migration in the embryonic cortex
Real-time imaging of migrating neurons has changed our understanding of how newborn neurons reach their final positions in the …
Cite
Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
Precise patterns of cell division and migration are crucial to transform the neuroepithelium of the embryonic forebrain into the adult …
Cite
Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors
Glycine and gamma-aminobutyric acid, type A (GABA(A)) receptors are members of the ligand-gated ion channel superfamily that mediate …
Cite
Radial glia diversity: a matter of cell fate
Early in development of the central nervous system, radial glial cells arise from the neuroepithelial cells lining the ventricles …
Cite
Neurogenic radial glial cells in reptile, rodent and human: from mitosis to migration
Radial glial cells play at least two crucial roles in cortical development: neuronal production in the ventricular zone (VZ) and the …
Cite
Neurons from radial glia: the consequences of asymmetric inheritance
Recent work suggests that radial glial cells represent many, if not most, of the neuronal progenitors in the developing cortex. …
Cite
Developmental neurotransmitters?
Previous studies support an early role for neurotransmitter signaling before synaptogenesis, but puzzlingly, a neurological phenotype …
Cite
Is there more to GABA than synaptic inhibition?
In the mature brain, GABA (gamma-aminobutyric acid) functions primarily as an inhibitory neurotransmitter. But it can also act as a …
Cite
Increased excitability and decreased sensitivity to GABA in an animal model of dysplastic cortex
PURPOSE: Cortical dysplasia (CD) is associated with epilepsy in both the pediatric and adult populations. The mechanism underlying …
Cite
Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia
The embryonic ventricular zone (VZ) of the cerebral cortex contains migrating neurons, radial glial cells, and a large population of …
Cite
GABA may act as a self-limiting trophic factor at developing synapses
Early in development, synapses with glycine or gamma-aminobutyric acid (GABA)-gated chloride channels exhibit the ability to depolarize …
Cite
Neurons derived from radial glial cells establish radial units in neocortex
The neocortex of the adult brain consists of neurons and glia that are generated by precursor cells of the embryonic ventricular zone. …
Cite
Maturation of channels and receptors: consequences for excitability
Cite
Transient actions of neurotransmitters during neocortical development
Cite
Extrinsic GABAergic innervation of developing neocortical layer 1 in organotypic slice co-cultures
Afferents from the zona incerta (ZI) of the ventral thalamus contribute to the dense, transient gamma-aminobutyric acid (GABA)ergic …
Cite
An excitatory GABAergic plexus in developing neocortical layer 1
Layer 1 of the developing rodent somatosensory cortex contains a dense, transient GABAergic fiber plexus. Axons arising from the zona …
Cite
Calcium dynamics of neocortical ventricular zone cells
Cell-cell signaling within the neocortical ventricular zone (VZ) has been shown to influence the proliferation of VZ precursor cells …
Cite
Leukoencephalopathy and raised brain lactate from heroin vapor inhalation (``chasing the dragon'')
BACKGROUND: Inhalation of heated heroin vapor (``chasing the dragon’’), which is gaining popularity among drug users …
Cite
Endogenous activation of metabotropic glutamate receptors in neocortical development causes neuronal calcium oscillations
Oscillations in intracellular free calcium concentration (Ca(2+)) occur spontaneously in immature neurons of the developing cerebral …
Cite
Changing properties of GABA(A) receptor-mediated signaling during early neocortical development
Evidence from several brain regions suggests gamma-aminobutyric acid (GABA) can exert a trophic influence during development, expanding …
Cite
Ontogeny of channels, transmitters and epileptogenesis
Cite
Patterns of intracellular calcium fluctuation in precursor cells of the neocortical ventricular zone
Changes in intracellular free calcium concentration ([Ca2+]i) are known to influence a variety of events in developing neurons. …
Cite
Nonsynaptic glycine receptor activation during early neocortical development
Glycine receptors (GlyRs) contribute to fast inhibitory synaptic transmission in the brain stem and spinal cord. GlyR subunits are …
Cite
Postnatal development of low [Mg2+] oscillations in neocortex
One form of rhythmic activity intrinsic to neocortex can be induced in slices of adult somatosensory cortex by lowering [Mg2+]o to …
Cite
Cell coupling and uncoupling in the ventricular zone of developing neocortex
Cells within the ventricular zone (VZ) of developing neocortex are coupled together into clusters by gap junction channels. The …
Cite
NR2A subunit expression shortens NMDA receptor synaptic currents in developing neocortex
NMDA receptors play important roles in learning and memory and in sculpting neural connections during development. After the period of …
Cite
Mechanisms underlying neuronal migration disorders and epilepsy
Neuronal migration disorders are often associated with intractable epilepsy. These cortical malformations are quite heterogeneous, …
Cite
Heroin inhalation and progressive spongiform leukoencephalopathy
Cite
Excitatory GABA responses in embryonic and neonatal cortical slices demonstrated by gramicidin perforated-patch recordings and calcium imaging
Gramicidin perforated-patch-clamp recordings in brain slices were used to obtain an accurate assessment of the developmental change in …
Cite
Cortical neurogenesis and its disorders
Proliferative cells lining the cerebral ventricles generate all of the phenotypically diverse neurons of the adult cortex. Recent …
Cite
GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis
We have found that, during the early stages of cortical neurogenesis, both GABA and glutamate depolarize cells in the ventricular zone …
Cite
Properties of amino acid neurotransmitter receptors of embryonic cortical neurons when activated by exogenous and endogenous agonists
  1. The properties of receptors for amino acid neurotransmitters expressed by developing cortical neurons were studied with the use of …
Cite
Abnormal action-potential bursts and synchronized, GABA-mediated inhibitory potentials in an in vitro model of focal epilepsy
Focal, freeze-induced lesions were made in isolated hemispheres of turtle cerebral cortex in vitro, permitting the investigation of …
Cite
Norepinephrine activates potassium conductance in neurons of the turtle cerebral cortex
Whole-cell voltage and current clamp recordings were obtained from cortical neurons of the pond turtle, Pseudemys scripta elegans. …
Cite
Spontaneous action potential activity and synaptic currents in the embryonic turtle cerebral cortex
We used loose-patch and whole-cell recording techniques to study the development of spontaneous action potential activity and …
Cite
Morphological differentiation of distinct neuronal classes in embryonic turtle cerebral cortex
As a starting point for understanding the development of the cerebral cortex in reptiles and for determining how reptilian cortical …
Cite
Appearance of putative amino acid neurotransmitters during differentiation of neurons in embryonic turtle cerebral cortex
Pyramidal and nonpyramidal neurons can be recognized early in the development of the cerebral cortex in both reptiles and mammals, and …
Cite
Clusters of coupled neuroblasts in embryonic neocortex
The neocortex of the brain develops from a simple germinal layer into a complex multilayer structure. To investigate cellular …
Cite
Initial expression and endogenous activation of NMDA channels in early neocortical development
We have made patch-clamp recordings from slices of fetal and postnatal rat neocortex in order to study the initial expression and …
Cite
Turtle cortical neurons survive glutamate exposures that are lethal to mammalian neurons
Glutamate is an excitatory neurotransmitter in turtle and mammalian cortex. In high concentrations it is toxic to mammalian neurons and …
Cite
Endogenous neurotransmitter activates N-methyl-D-aspartate receptors on differentiating neurons in embryonic cortex
Before synapses form in embryonic turtle cerebral cortex, an endogenous neurotransmitter activates N-methyl-D-aspartate (NMDA) channels …
Cite
Differential activation of glutamate receptors by spontaneously released transmitter in slices of neocortex
Whole-cell recordings were made from neurons in neocortical brain slices in order to characterize excitatory synaptic currents mediated …
Cite
Whole cell recording from neurons in slices of reptilian and mammalian cerebral cortex
We describe methods for obtaining stable, whole-cell recordings from neurons in brain hemispheres from turtles and in brain slices from …
Cite
The development of bicuculline-induced epileptiform discharges in embryonic turtle cortex
The appearance of bicuculline-induced epileptiform discharges was studied in embryonic turtle cortex using extracellular recording …
Cite
Development of GABA responsiveness in embryonic turtle cortical neurons
The whole-cell patch-clamp method was used to study the development of functional GABA receptors in cortical neurons dissociated from …
Cite
Quantitative autoradiography of muscarinic and benzodiazepine receptors in the forebrain of the turtle, Pseudemys scripta
The distribution of muscarinic and benzodiazepine receptors was investigated in the turtle forebrain by the technique of in vitro …
Cite
Synaptic responses of cortical pyramidal neurons to light stimulation in the isolated turtle visual system
The resistance of the turtle brain to hypoxic injury permits a unique in vitro preparation in which the organization and function of …
Cite
Cellular and synaptic physiology and epileptogenesis of developing rat neocortical neurons in vitro
The cellular and synaptic physiology of developing rat neocortical neurons was studied using the in vitro slice method. Rats aged 1-28 …
Cite
Evidence for the inhibitory neurotransmitter gamma-aminobutyric acid in aspiny and sparsely spiny nonpyramidal neurons of the turtle dorsal cortex
In order to learn more about the anatomical substrate for gamma-aminobutyric acid (GABA)-mediated inhibition in cortical structures, …
Cite
Glutamate neurotoxicity in cortical cell culture
The central neurotoxicity of the excitatory amino acid neurotransmitter glutamate has been postulated to participate in the …
Cite
Turtle hippocampal cortex contains distinct cell types, burst-firing neurons, and an epileptogenic subfield
The dorsal and medial telencephalon of reptiles consists of a simple trilaminar cortex. The turtle dorsal cortex has been identified as …
Cite
Monoclonal antibodies to the turtle cortex reveal neuronal subsets, antigenic cross-reactivity with the mammalian neocortex, and forebrain structures sharing a pallial derivation
The dorsal cortex of the pond turtle (Pseudemys scripta) is a relatively simple structure consisting of two principal classes of …
Cite
Cellular physiology of the turtle visual cortex: synaptic properties and intrinsic circuitry
We have examined the synaptic physiology of the isolated dorsal cortex of the turtle, Pseudemys scripta elegans. Electrical stimulation …
Cite
Cellular physiology of the turtle visual cortex: distinctive properties of pyramidal and stellate neurons
The electrophysiological properties of neurons in the three-layered dorsal cortex of the turtle, Pseudemys scripta elegans, have been …
Cite
The influence of dopamine on epileptiform burst activity in hippocampal pyramidal neurons
Dopamine (DA) application to guinea pig hippocampal CA1 neurons in vitro causes hyperpolarization of the resting potential, increase in …
Cite
Morphological classification of rat cortical neurons in cell culture
Neurons in ``mature’’ (4- to 6-week-old) dissociated cell cultures of 15-day gestational age rat fetal cortex were injected …
Cite
Cholinergic enhancement of penicillin-induced epileptiform discharges in pyramidal neurons of the guinea pig hippocampus
Acetylcholine (1-20 mM) was applied to guinea pig hippocampal slices bathed in normal and penicillin-containing media. Recordings in …
Cite
Neurology-important advances in clinical medicine: treatment of febrile convulsions
Cite
Stages in the post-hatching development of Aplysia californica
In order to study the development of the nervous system of the marine mollusc, Aplysia californica, it is necessary objectively to …
Cite
Development of the nervous system of Aplysia californica
The ability to grow the marine molluse Aplysia under laboratory conditions allows a detailed study of the formation of the nervous …
Cite
Metamorphosis of Aplysia californica in laboratory culture
To utilize the advantages offered by the large identified nerve cells of the marine mollusc Aplysia californica for cellular biological …
Cite