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Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells
Radial glial progenitor cells exhibit bidirectional cell cycle-dependent nuclear oscillations. The purpose and underlying mechanism of …
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Blocking early GABA depolarization with bumetanide results in permanent alterations in cortical circuits and sensorimotor gating deficits
A high incidence of seizures occurs during the neonatal period when immature networks are hyperexcitable and susceptible to …
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Connexin 43 mediates the tangential to radial migratory switch in ventrally derived cortical interneurons
The adult cerebral cortex is composed of excitatory and inhibitory neurons that arise from progenitor cells in disparate proliferative …
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Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats
We investigated a strategy to ameliorate the motor symptoms of rats that received 6-hydroxydopamine (6-OHDA) lesions, a rodent model of …
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Neurogenic radial glia in the outer subventricular zone of human neocortex
Neurons in the developing rodent cortex are generated from radial glial cells that function as neural stem cells. These epithelial …
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Regenerative medicine: Cell reprogramming gets direct
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Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex
Asymmetric cell division of radial glial progenitors produces neurons while allowing self-renewal; however, little is known about the …
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Commentary: the prospect of cell-based therapy for epilepsy
About 30% of patient with epilepsy do not respond to available antiepileptic drugs. In addition to seizure suppression, novel …
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Defining the role of GABA in cortical development
Of the many signals in the developing nervous system, GABA (gamma-aminobutyric acid) has been shown to be one of the earliest …
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Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development
The development of glutamatergic synapses involves changes in the number and type of receptors present at the postsynaptic density. To …
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