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SnapShot: cortical development
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Stem cells in the land of the rising sun: ISSCR 2012
The 2012 annual meeting of the International Society for Stem Cell Research (ISSCR) marked the Tenth Anniversary of the ISSCR. Held in …
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OSVZ progenitors in the human cortex: an updated perspective on neurodevelopmental disease
Recent discoveries concerning the architecture and cellular dynamics of the developing human brain are revealing new differences …
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Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation
The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that …
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Orienting fate: spatial regulation of neurogenic divisions
Cleavage plane orientation has been thought to govern the fate of neural stem cell progeny, but supporting evidence in the neocortex …
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Development and evolution of the human neocortex
The size and surface area of the mammalian brain are thought to be critical determinants of intellectual ability. Recent studies show …
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Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity
Neural stem cells (NSCs) persist in the subventricular zone (SVZ) of the adult brain. Location within this germinal region determines …
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Deriving excitatory neurons of the neocortex from pluripotent stem cells
The human cerebral cortex is an immensely complex structure that subserves critical functions that can be disrupted in developmental …
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A new subtype of progenitor cell in the mouse embryonic neocortex
A hallmark of mammalian brain evolution is cortical expansion, which reflects an increase in the number of cortical neurons established …
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Developmental genetics of vertebrate glial-cell specification
Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous system. These cells have diverse roles in the …
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