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Control of outer radial glial stem cell mitosis in the human brain
Evolutionary expansion of the human neocortex is partially attributed to a relative abundance of neural stem cells in the fetal brain …
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Interneurons from embryonic development to cell-based therapy
Many neurologic and psychiatric disorders are marked by imbalances between neural excitation and inhibition. In the cerebral cortex, …
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Diverse behaviors of outer radial glia in developing ferret and human cortex
The dramatic increase in neocortical size and folding during mammalian brain evolution has been attributed to the elaboration of the …
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Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells
Ring chromosomes are structural aberrations commonly associated with birth defects, mental disabilities and growth retardation. Rings …
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The dynamics of neuronal migration
Proper lamination of the cerebral cortex is precisely orchestrated, especially when neurons migrate from their place of birth to their …
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Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences
GABAergic cortical interneurons underlie the complexity of neural circuits and are particularly numerous and diverse in humans. In …
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Cerebral organoids in a dish: progress and prospects
A three-dimensional culture of cortical tissues derived from pluripotent stem cells offers an opportunity to model human brain …
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A high-resolution enhancer atlas of the developing telencephalon
The mammalian telencephalon plays critical roles in cognition, motor function, and emotion. Though many of the genes required for its …
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Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex
The human neocortex is increased in size and complexity as compared with most other species. Neocortical expansion has recently been …
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Regulation of microtubule stability and organization by mammalian Par3 in specifying neuronal polarity
Polarization of mammalian neurons with a specified axon requires precise regulation of microtubule and actin dynamics in the developing …
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