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Neuroserpin expression during human brain development and in adult brain revealed by immunohistochemistry and single cell RNA sequencing
Neuroserpin is a serine-protease inhibitor mainly expressed in the CNS and involved in the inhibition of the proteolytic cascade. …
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Does Adult Neurogenesis Persist in the Human Hippocampus?
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Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development
MicroRNAs (miRNAs) regulate many cellular events during brain development by interacting with hundreds of mRNA transcripts. However, …
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Identification of cell types in a mouse brain single-cell atlas using low sampling coverage
BACKGROUND: High throughput methods for profiling the transcriptomes of single cells have recently emerged as transformative approaches …
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Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity
The neocortex of primates, including humans, contains more abundant and diverse inhibitory neurons compared with rodents, but the …
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An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder
Genomic association studies of common or rare protein-coding variation have established robust statistical approaches to account for …
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Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
New neurons continue to be generated in the subgranular zone of the dentate gyrus of the adult mammalian hippocampus. This process has …
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Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment
BACKGROUND: Tumor-associated macrophages (TAMs) are abundant in gliomas and immunosuppressive TAMs are a barrier to emerging …
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Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex
Systematic analyses of spatiotemporal gene expression trajectories during organogenesis have been challenging because diverse cell …
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The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas
A comprehensive characterization of neuronal cell types, their distributions, and patterns of connectivity is critical for …
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