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Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog
Neural stem cells (NSCs) in the prenatal neocortex progressively generate different subtypes of glutamatergic projection neurons. …
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Cell stress in cortical organoids impairs molecular subtype specification
Cortical organoids are self-organizing three-dimensional cultures that model features of the developing human cerebral cortex(1,2). …
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Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma
Glioblastoma is a devastating form of brain cancer. To identify aspects of tumor heterogeneity that may illuminate drivers of tumor …
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Neuroglial stem cell-derived inflammatory pseudotumor (n-SCIPT): clinicopathologic characterization of a novel lesion of the lumbosacral spinal cord and nerve roots following intrathecal allogeneic stem cell intervention
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Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation
Pelizaeus-Merzbacher disease (PMD) is an X-linked leukodystrophy caused by mutations in Proteolipid Protein 1 (PLP1), encoding a major …
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Neuronal vulnerability and multilineage diversity in multiple sclerosis
Multiple sclerosis (MS) is a neuroinflammatory disease with a relapsing-remitting disease course at early stages, distinct lesion …
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Immature excitatory neurons develop during adolescence in the human amygdala
The human amygdala grows during childhood, and its abnormal development is linked to mood disorders. The primate amygdala contains a …
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Single-cell genomics identifies cell type-specific molecular changes in autism
Despite the clinical and genetic heterogeneity of autism, bulk gene expression studies show that changes in the neocortex of autism …
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Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution
Direct comparisons of human and non-human primate brains can reveal molecular pathways underlying remarkable specializations of the …
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Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex
In the developing human neocortex, progenitor cells generate diverse cell types prenatally. Progenitor cells and newborn neurons …
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