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Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) readily infects a variety of cell types impacting the function of …
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Cell-type-specific 3D epigenomes in the developing human cortex
Lineage-specific epigenomic changes during human corticogenesis have been difficult to study owing to challenges with sample …
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Are Organoids Ready for Prime Time?
Innovations in organoid-based models of human tissues have made them an exciting experimental platform for studying development and …
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mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex
Outer radial glial (oRG) cells are a population of neural stem cells prevalent in the developing human cortex that contribute to its …
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Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies
CD19-directed immunotherapies are clinically effective for treating B cell malignancies but also cause a high incidence of …
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Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency
Aberrant aggregation of the RNA-binding protein TDP-43 in neurons is a hallmark of frontotemporal lobar degeneration caused by …
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Origins and Proliferative States of Human Oligodendrocyte Precursor Cells
Human cerebral cortex size and complexity has increased greatly during evolution. While increased progenitor diversity and enhanced …
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A Chromatin Accessibility Atlas of the Developing Human Telencephalon
To discover regulatory elements driving the specificity of gene expression in different cell types and regions of the developing human …
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Identification of amygdala-expressed genes associated with autism spectrum disorder
BACKGROUND: Studies of individuals with autism spectrum disorder (ASD) have revealed a strong multigenic basis with the identification …
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SMART-Q: An Integrative Pipeline Quantifying Cell Type-Specific RNA Transcription
Accurate RNA quantification at the single-cell level is critical for understanding the dynamics of gene expression and regulation …
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