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Changing properties of GABA(A) receptor-mediated signaling during early neocortical development
Evidence from several brain regions suggests gamma-aminobutyric acid (GABA) can exert a trophic influence during development, expanding …
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Ontogeny of channels, transmitters and epileptogenesis
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Patterns of intracellular calcium fluctuation in precursor cells of the neocortical ventricular zone
Changes in intracellular free calcium concentration ([Ca2+]i) are known to influence a variety of events in developing neurons. …
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Nonsynaptic glycine receptor activation during early neocortical development
Glycine receptors (GlyRs) contribute to fast inhibitory synaptic transmission in the brain stem and spinal cord. GlyR subunits are …
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Postnatal development of low [Mg2+] oscillations in neocortex
One form of rhythmic activity intrinsic to neocortex can be induced in slices of adult somatosensory cortex by lowering [Mg2+]o to …
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Cell coupling and uncoupling in the ventricular zone of developing neocortex
Cells within the ventricular zone (VZ) of developing neocortex are coupled together into clusters by gap junction channels. The …
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Mechanisms underlying neuronal migration disorders and epilepsy
Neuronal migration disorders are often associated with intractable epilepsy. These cortical malformations are quite heterogeneous, …
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NR2A subunit expression shortens NMDA receptor synaptic currents in developing neocortex
NMDA receptors play important roles in learning and memory and in sculpting neural connections during development. After the period of …
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Heroin inhalation and progressive spongiform leukoencephalopathy
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Excitatory GABA responses in embryonic and neonatal cortical slices demonstrated by gramicidin perforated-patch recordings and calcium imaging
Gramicidin perforated-patch-clamp recordings in brain slices were used to obtain an accurate assessment of the developmental change in …
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