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Neural stem and progenitor cells in cortical development
Recent work has begun to identify neural stem and progenitor cells in the embryonic and adult brain, and is unravelling the mechanisms …
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Estradiol stimulates progenitor cell division in the ventricular and subventricular zones of the embryonic neocortex
Two distinct populations of cerebral cortical progenitor cells that generate neurons during embryogenesis have been identified: radial …
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Characterization of mice with targeted deletion of glycine receptor alpha 2
Glycine receptors are ligand-gated chloride channels that mediate inhibitory neurotransmission in the adult nervous system. During …
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The role of intermediate progenitor cells in the evolutionary expansion of the cerebral cortex
The vertebrate cerebral cortex varies from the 3-layered dorsal cortex of reptiles to the 6-layered lissencephalic cortex …
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Blind patch clamp recordings in embryonic and adult mammalian brain slices
To obtain electrophysiological recordings in brain slices, sophisticated and expensive pieces of equipment can be used. However, costly …
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A new era in the ethics of human embryonic stem cell research
Scientific progress in human embryonic stem cell (hESC) research and increased funding make it imperative to look ahead to the ethical …
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GABA puts the brake on stem cells
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LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages
Mutations in the human LIS1 gene cause the smooth brain disease classical lissencephaly. To understand the underlying mechanisms, we …
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Constructing circuits: neurogenesis and migration in the developing neocortex
Our knowledge of the proliferation, migration, and differentiation of neurons has changed dramatically over the last 10 years. Whereas …
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Calcium waves propagate through radial glial cells and modulate proliferation in the developing neocortex
The majority of neurons in the adult neocortex are produced embryonically during a brief but intense period of neuronal proliferation. …
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