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A time and a place for nkx2-1 in interneuron specification and migration
The homeobox transcription factor, Nkx2-1, plays multiple roles during forebrain development. Using restricted genetic ablation of …
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GABA regulates stem cell proliferation before nervous system formation
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Progenitors from the postnatal forebrain subventricular zone differentiate into cerebellar-like interneurons and cerebellar-specific astrocytes upon transplantation
Forebrain subventricular zone (SVZ) progenitor cells give rise to glia and olfactory bulb interneurons during early postnatal life in …
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Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis
Neocortical precursor cells undergo symmetric and asymmetric divisions while producing large numbers of diverse cortical cell types. In …
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GABA regulates excitatory synapse formation in the neocortex via NMDA receptor activation
The development of a balance between excitatory and inhibitory synapses is a critical process in the generation and maturation of …
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Manipulating midbrain stem cell self-renewal
In this issue of Cell Stem Cell, Falk and colleagues (Falk et al., 2008) demonstrate that differential responsiveness to TGF-beta …
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Gap junctions: multifaceted regulators of embryonic cortical development
The morphological development of the cerebral cortex from a primitive neuroepithelium into a complex laminar structure underlying …
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Gap junction adhesion is necessary for radial migration in the neocortex
Radial glia, the neuronal stem cells of the embryonic cerebral cortex, reside deep within the developing brain and extend radial fibres …
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Cortical neurogenesis: transitioning from advances in the laboratory to cell-based therapies
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Contribution of intermediate progenitor cells to cortical histogenesis
The mammalian cerebral cortex is the most cellularly complex structure in the animal kingdom. Almost all cortical neurons are produced …
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