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A nomenclature consensus for nervous system organoids and assembloids
Self-organizing three-dimensional cellular models derived from human pluripotent stem cells or primary tissue have great potential to …
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Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain
Interactions between angiogenesis and neurogenesis regulate embryonic brain development. However, a comprehensive understanding of the …
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How mechanisms of stem cell polarity shape the human cerebral cortex
Apical-basal progenitor cell polarity establishes key features of the radial and laminar architecture of the developing human cortex. …
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Tropism of SARS-CoV-2 for human cortical astrocytes
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) readily infects a variety of cell types impacting the function of …
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Zika virus alters centrosome organization to suppress the innate immune response
Zika virus (ZIKV) is a flavivirus transmitted via mosquitoes and sex to cause congenital neurodevelopmental defects, including …
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Identification of Lipid Heterogeneity and Diversity in the Developing Human Brain
The lipidome is currently understudied but fundamental to life. Within the brain, little is known about cell-type lipid heterogeneity, …
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An atlas of cortical arealization identifies dynamic molecular signatures
The human brain is subdivided into distinct anatomical structures, including the neocortex, which in turn encompasses dozens of …
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Distinct nuclear compartment-associated genome architecture in the developing mammalian brain
Nuclear compartments are thought to play a role in three-dimensional genome organization and gene expression. In mammalian brain, the …
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Human intermediate progenitor diversity during cortical development
Studies of the spatiotemporal, transcriptomic, and morphological diversity of radial glia (RG) have spurred our current models of human …
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Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia
The human cortex comprises diverse cell types that emerge from an initially uniform neuroepithelium that gives rise to radial glia, the …
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